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Article
Immune prevention of mammary carcinogenesis in HER-2/neu transgenic mice: a microarray scenario
Neoplastic transformation is a multistep process in which gene products of specific regulatory pathways are involved at each stage. Identification of these overexpressed or mutated gene products provides an un...
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Article
Development of a murine orthotopic model of leukemia: Evaluation of TP53 gene therapy efficacy
The onco-suppressor gene TP53 has potential use in the gene therapy of many human cancers including leukemias. The latter indication derived from numerous experimental reports of p53-mediated suppressing effects ...
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Article
Inhibition of Lung Colonisation of a Mouse Mammary Carcinoma by Therapeutic Vaccination with Interferon-α Gene-Transduced Tumor Cells
A spontaneously metastatic murine mammary adenocarcinoma, TSA, has been transduced with the gene for interferon α1 (IFN-α). Transfectants were used for the immunotherapy of mice bearing lung colonies induced b...
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Article
Alpha-1-antitrypsin in umbilical cord serum: Pi phenotypes and relationships with idiopathic respiratory distress syndrome
The concentrations and phenotypes of serum alpha-1-antitrypsin (αIAT) were determined in 650 newborn infants.