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  1. Article

    Open Access

    In silico, in vitro and in vivo characterization of host-associated Latilactobacillus curvatus strains for potential probiotic applications in farmed Atlantic salmon (Salmo salar)

    Salmon aquaculture is the fastest growing animal protein production system in the world; however, intensive farming leads to poor weight gain, stress, and disease outbreaks. Probiotics offer the potential to e...

    Hannah S. Cathers, Shrinivasrao P. Mane, Nilesh R. Tawari in Scientific Reports (2022)

  2. Article

    Open Access

    Growth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome

    Antimicrobial growth promoters (AGP) have played a decisive role in animal agriculture for over half a century. Despite mounting concerns about antimicrobial resistance and demand for antibiotic alternatives, ...

    Germán Plata, Nielson T. Baxter, Dwi Susanti in Communications Biology (2022)

  3. No Access

    Article

    Long-term phenotypic evolution of bacteria

    A comparative analysis of bacterial growth and genetic phenotypes using hundreds of genome-scale metabolic models reveals a two-stage evolutionary process that consists of a rapid initial phenotypic diversific...

    Germán Plata, Christopher S. Henry, Dennis Vitkup in Nature (2015)

  4. No Access

    Article

    Global probabilistic annotation of metabolic networks enables enzyme discovery

    A new global annotation strategy combines sequence identity and genomic context to provide probabilities for all metabolic assignments in a given species. Application of this method leads to multiple new annot...

    Germán Plata, Tobias Fuhrer, Tzu-Lin Hsiao, Uwe Sauer in Nature Chemical Biology (2012)

  5. Article

    Open Access

    The rate of the molecular clock and the cost of gratuitous protein synthesis

    The nature of the protein molecular clock, the protein-specific rate of amino acid substitutions, is among the central questions of molecular evolution. Protein expression level is the dominant determinant of ...

    Germán Plata, Max E Gottesman, Dennis Vitkup in Genome Biology (2010)

  6. Article

    Open Access

    Sequencing analysis of 20,000 full-length cDNA clones from cassava reveals lineage specific expansions in gene families related to stress response

    Cassava, an allotetraploid known for its remarkable tolerance to abiotic stresses is an important source of energy for humans and animals and a raw material for many industrial processes. A full-length cDNA li...

    Tetsuya Sakurai, Germán Plata, Fausto Rodríguez-Zapata, Motoaki Seki in BMC Plant Biology (2007)