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Article
Open AccessIn silico, in vitro and in vivo characterization of host-associated Latilactobacillus curvatus strains for potential probiotic applications in farmed Atlantic salmon (Salmo salar)
Salmon aquaculture is the fastest growing animal protein production system in the world; however, intensive farming leads to poor weight gain, stress, and disease outbreaks. Probiotics offer the potential to e...
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Article
Open AccessGrowth promotion and antibiotic induced metabolic shifts in the chicken gut microbiome
Antimicrobial growth promoters (AGP) have played a decisive role in animal agriculture for over half a century. Despite mounting concerns about antimicrobial resistance and demand for antibiotic alternatives, ...
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Article
Long-term phenotypic evolution of bacteria
A comparative analysis of bacterial growth and genetic phenotypes using hundreds of genome-scale metabolic models reveals a two-stage evolutionary process that consists of a rapid initial phenotypic diversific...
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Article
Global probabilistic annotation of metabolic networks enables enzyme discovery
A new global annotation strategy combines sequence identity and genomic context to provide probabilities for all metabolic assignments in a given species. Application of this method leads to multiple new annot...
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Open AccessThe rate of the molecular clock and the cost of gratuitous protein synthesis
The nature of the protein molecular clock, the protein-specific rate of amino acid substitutions, is among the central questions of molecular evolution. Protein expression level is the dominant determinant of ...
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Article
Open AccessSequencing analysis of 20,000 full-length cDNA clones from cassava reveals lineage specific expansions in gene families related to stress response
Cassava, an allotetraploid known for its remarkable tolerance to abiotic stresses is an important source of energy for humans and animals and a raw material for many industrial processes. A full-length cDNA li...