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Prolonged HPA axis dysregulation in postpartum depression associated with adverse early life experiences: a cross-species translational study

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  1. Article

    Open Access

    Type 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation of FKBP5

    Subclinical hypercortisolism and hypothalamic-pituitary-adrenal (HPA) axis dysfunction are associated with type 2 diabetes (T2DM), cardiovascular disease, and metabolic dysfunction. Intronic methylation of FKBP5 ...

    Robin Ortiz, Joshua J. Joseph, Richard Lee, Gary S. Wand… in Clinical Epigenetics (2018)

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  2. Article

    Differences in δ- and μ-Opioid Receptor Blockade Measured by Positron Emission Tomography in Naltrexone-Treated Recently Abstinent Alcohol-Dependent Subjects

    Blockade of brain μ-opioid receptor (μ-OR) and δ-opioid receptor (δ-OR) was investigated in recently abstinent alcohol-dependent subjects (N=21) maintained on naltrexone. Subjects completed a 19-day inpatient pro...

    Elise M Weerts, Yu Kyeong Kim, Gary S Wand, Robert F Dannals… in Neuropsychopharmacology (2008)

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  3. Article

    Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress

    Preclinical studies have shown that stress and glucocorticoids increase mesolimbic dopamine (DA) and thereby facilitate psychostimulant self-administration. The relationship between stress-induced cortisol and...

    Gary S Wand, Lynn M Oswald, Mary E McCaul, Dean F Wong… in Neuropsychopharmacology (2007)

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  4. Article

    Hormonal Responses to Psychological Stress and Family History of Alcoholism

    The present study was designed to determine whether stress hormones and subjective responses to a psychological stressor were different in nonalcoholic offspring from families with a history of alcohol depende...

    Magdalena Uhart, Lynn Oswald, Mary E McCaul, Rachel Chong… in Neuropsychopharmacology (2006)

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  5. Article

    Relationship between Cortisol Responses to Stress and Personality

    Although there is growing evidence of links between the cortisol stress response and personality, the nature of the relationships and the underlying mechanisms require further clarification. The purpose of thi...

    Lynn M Oswald, Peter Zandi, Gerald Nestadt, James B Potash… in Neuropsychopharmacology (2006)

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  6. Article

    The Mu-Opioid Receptor Polymorphism A118G Predicts Cortisol Responses to Naloxone and Stress

    A polymorphism in the mu-opioid receptor (MOR) (A118G) has been shown to increase β-endorphin binding affinity, theoretically placing greater inhibitory tone on hypothalamic corticotropin-releasing hormone (CRH) ...

    Rachel Y Chong, Lynn Oswald, **aoju Yang, Magdalena Uhart… in Neuropsychopharmacology (2006)

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  7. Article

    Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine

    There is evidence that stress and glucocorticoids alter drug self-administration and mesolimbic dopamine (DA) activity in preclinical models. The primary purpose of this study was to test the hypothesis that g...

    Lynn M Oswald, Dean F Wong, Mary McCaul, Yun Zhou… in Neuropsychopharmacology (2005)

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