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Article
Cytotoxicity of chloral-derived β-carbolines is not specific towards neuronal nor dopaminergic cells
β-Carbolines structurally related to the selective dopaminergic neurotoxin 1-methyl-4- phenylpyridinium (MPP+) may contribute to dopaminergic neurodegeneration in Parkinson’s disease. The chloral-derived mammalia...
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Article
Proteomics of the human brain: sub-proteomes might hold the key to handle brain complexity
Proteomics is a promising approach, which provides information about the expression of proteins and increasingly finds application in life science and disease research. Meanwhile, proteomics has proven to be a...
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Article
Subcellular proteomics reveals neuromelanin granules to be a lysosome-related organelle
The powerful combination of subcellular fractionation and protein identification by electrospray ionization tandem mass spectrometry (ESI-MS/MS) pioneered the molecular elucidation of neuromelanin (NM) granule...
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Chapter
Full Absolute Stereostructures of Natural Products Directly from Crude Extracts: The HPLC-MS/MS-NMR-CD ‘Triad’
This chapter deals with an efficient methodology available in our Center of Excellence, BIOTECmarin: the novel analytical ‘triad’ HPLC-MS/ MS-NMR-CD. By this method, which was, in this complemented form, first...
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Chapter
Sorbicillactone A: a Structurally Unprecedented Bioactive Novel-Type Alkaloid from a Sponge-Derived Fungus
This chapter deals with the discovery of sorbicillactone A, as an illustrative example of the fruitful cooperation within BIOTECmarin — its isolation and chemical characterization, and its biological activitie...
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Article
In vitro germination and establishment of tissue cultures of Bulbine caulescens and of two Kniphofia species (Asphodelaceae)
A protocol for the in vitro germination and the establishment of tissue cultures of Bulbine caulescens Linn., Kniphofia pumila Kunth, and K. uvaria Hook has been developed. The members of the family Asphodelacea...
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Article
In vitro propagation of the alkaloid-producing rare African liana, Triphyophyllum peltatum (Dioncophyllaceae)
Triphyophyllum peltatum (Dioncophyllaceae), a West African liana containing pharmaceutically promising naphthylisoquinoline alkaloids, has successfully been raised in vitro. A clonal propagation protocol has been...
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Article
A comparison of the stage-specific efficacy of chloroquine, artemether and dioncophylline B against the rodent malaria parasite Plasmodium chabaudi chabaudi in vivo
Chloroquine, artemether and dioncophylline B efficacy against Plasmodium chabaudi was compared. One intraperitoneal injection (10 mg/kg body weight) was given daily over 3 consecutive days to OF1 mice when they ...
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Article
In vivo19F NMR chemical-shift imaging ofAncistrocladus species
19F nuclear magnetic resonance (NMR) imaging and19F NMR chemical-shift imaging (19F CSI) have been used to localize fluorinated compounds administered to stems ofAncistrocladus heyneanus andA. abbreviatus for th...
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Chapter
Biaryls in Nature: A Multi-Facetted Class of Stereochemically, Biosynthetically, and Pharmacologically Intriguing Secondary Metabolites
The biaryl axis is the joint central structural element of a broad variety of structurally (in particular stereochemically) and biosynthetically interesting as well as pharmacologically promising natural produ...
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Chapter
Deleterious Effects of Highly Halogenated ß-Carbolines on Dopaminergic Cells in Culture and on Mitochondrial Respiration
Several psychotropically active ß-carbolines (e.g. harmane, norharman, harmin, and especially their N-methylated derivatives) have been described to exert neurotoxic effects to dopaminergic cells comparable to th...
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Chapter
Effects of TaClo (1-Trichloromethyl-1,2,3,4-Tetrahydro-ß-Carboline) on Mice Neuronal Culture and Possibilities of Cellular Regeneration in Vitro after Toxin Withdrawal
TaClo (l-trichloromethyl-1,2, 3,4-tetrahydro-b-carboline), a highly chlorinated tetrahydro-ß-carboline is known to exert neurotoxic effects an the dopaminergic system both in vivo and in vitro. Toxicity may deriv...
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Article
In vitro propagation of Ancistrocladus abbreviatus Airy Shaw (Ancistrocladaceae)
Ancistrocladus abbreviatus Airy Shaw (Ancistrocladaceae), a West African liana producing naphthylisoquinoline alkaloids, was successfully raised from seeds in vitro. Clonal propagation was best achieved growin...
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Article
Nuclear magnetic resonance microscopy ofAncistrocladus heyneanus
The tropical lianaAncistrocladus heyneanus, which is known for its biologically active naphthylisoquinoline alkaloids, has been studied by nuclear magnetic resonance (NMR) microscopy for the first time. The spati...
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Chapter
In Vitro- and in Vivo-Studies of Alkaloids in the Liana Ancistrocladus Heyneanus
Ancistrocladus heyneanus, an Indian member of the tropical plant family of the Ancistrocladaceae, is known to produce naphthylisochinoline alkaloids as secondary metabolites [1]. These compounds are of interes...
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Chapter
Progressive Neurodegeneration of the Dopaminergic system and Inhibition of the Complex I Induced by the Chloral-Derived Tetrahydro-β-Carboline TaClo
TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) appears to be a neurotoxic drug able to induce a slow develo** degeneration of dopamine neurons. This is indicated from measurements of the apomorphin...
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Article
Abstracts Second Congress of the European Society for Clinical Neuropharmacology
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Article
In vivo formation of diazepam-like 1,4-benzodiazepines byPenicillium verrucosum var.verrucosum after administration of 2-aminobenzophenones and glycine
The in vivo formation of the diazepam-like 1,4-benzodiazepine deschloronordiazepam from its assumed biogenetic precursors, 2-aminobenzophenone and glycine, by the mould strainPenicillium verrucosum var.verrucosum
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Article
A first biosynthetic proposal for the in vivo formation of naturally occurring diazepam-like 1,4-benzodiazepines
A first rational concept for the in vivo formation of naturally occurring diazepam-type 1,4-benzodiazepines is suggested — by oxidative carbon-carbon bond cleavage of the known quinoline alkaloid viridicatin, ...
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Chapter
In Vivo Characterization of NADPH: 2′-Hydroxyisoflavone Oxidoreductase in Elicitor Treated Chickpea Cell Cultures and Stereochemical Aspects of the Phytoalexins Medicarpin and Maackiain
Pterocarpan phytoalexins such as medicarpin, maackiain, phaseollin, pisatin or the various isomers of glyceollin are antimicrobial compounds synthesized by plant species of the Leguminosae in response to stress, ...
