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Cytotoxicity of chloral-derived β-carbolines is not specific towards neuronal nor dopaminergic cells
β-Carbolines structurally related to the selective dopaminergic neurotoxin 1-methyl-4- phenylpyridinium (MPP+) may contribute to dopaminergic neurodegeneration in Parkinson’s disease. The chloral-derived mammalia...
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Progressive Neurodegeneration of the Dopaminergic system and Inhibition of the Complex I Induced by the Chloral-Derived Tetrahydro-β-Carboline TaClo
TaClo (1-trichloromethyl-1,2,3,4-tetrahydro-β-carboline) appears to be a neurotoxic drug able to induce a slow develo** degeneration of dopamine neurons. This is indicated from measurements of the apomorphin...
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Abstracts Second Congress of the European Society for Clinical Neuropharmacology