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Article
Open AccessThe impact of genome evolution on the allotetraploid Nicotiana rustica – an intriguing story of enhanced alkaloid production
Nicotiana rustica (Aztec tobacco), like common tobacco (Nicotiana tabacum), is an allotetraploid formed through a recent hybridization event; however, it originated from completely different progenitor species. H...
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Article
Electrochemical Properties of Overoxidized Poly-3,4-Ethylenedioxythiophene
The properties of poly(3,4-ethylenedioxythiophene) (PEDOT) films were studied electrochemically at high positive potentials (from–0.3 to 1.5 V relative to the Ag/AgCl electrode). A cyclic voltammetry (CV) stud...
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Article
Open AccessKi67 index is an independent prognostic factor in epithelioid but not in non-epithelioid malignant pleural mesothelioma: a multicenter study
Estimating the prognosis in malignant pleural mesothelioma (MPM) remains challenging. Thus, the prognostic relevance of Ki67 was studied in MPM.
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Chapter
Grenzen der pulmonalen Metastasektomie
Die pulmonale Metastasektomie ist heute ein fixer Bestandteil der interdisziplinären Behandlung von Krebspatienten. Die Verschränkung lokaler, chirurgischer und systemisch-chemotherapeutischer Therapiekonzepte...
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Article
Lysyl oxidase enzymatic function increases stiffness to drive colorectal cancer progression through FAK
The extracellular, matrix-modifying enzyme lysyl oxidase (LOX) has recently been linked to colorectal cancer (CRC) progression, in particular to the stages of invasion and metastasis. In this report, we use ce...
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Article
Lebensqualität älterer Frauen bei Abhängigkeit und Gewalt
Lebensqualität wird maßgeblich durch sich biographisch verändernde Handlungskontexte bestimmt. Im hohen Alter gehören Gesundheit und soziale Beziehungen zu den zentralen Determinanten für ein „gutes Leben“. Ei...
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Article
Pulmonary metastasectomy
BACKGROUND: The major obstacle in curing cancer is the limited ability to prevent and treat metastatic disease. Pulmonary metastasectomy is now a standard treatment option in carefully selected cases. With the...
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Article
Endovaskuläre Versorgung der traumatischen Aortenruptur im Akutstadium
Seit März 1999 wurden bei 48 Patienten 52 Stentgraftsysteme unmittelbar posttraumatisch im Akutstadium der thorakalen Aortenruptur innerhalb der Polytraumaprimärversorgung appliziert. Bei Aortendurchmessern vo...
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Chapter and Conference Paper
Prospektive, randomisierte und kontrollierte Studie zur Evaluation eines »Fast track« Behandlungskonzeptes in der Aneurysmachirurgie
Background: Fast track programs — multimodal therapy strategies — have been introduced in many surgical fields to minimize postoperative morbidity and mortality. Morbidity after elective open inf...
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Chapter and Conference Paper
«Fast track» in der Aneurysmachirurgie — erste Ergebnisse einer prospektiven, randomisierten und kontrollierten Studie
Background: Despite advances in perioperative patient care major surgical procedures are still associated with certain morbidity and mortality. Open abdominal aortic aneurysm repair is related to...
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Article
Randomly fractionally integrated processes
Philippe et al. [9], [10] introduced two distinct time-varying mutually invertible fractionally integrated filters A(d), B(d) depending on an arbitrary sequence d = (d t
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Article
Allozyme and mitochondrial DNA analysis of French red deer (Cervus elaphus) populations: genetic structure and its implications for management and conservation
A total of 472 red deer, ervus elaphus, from 16 free-ranging populations in France were examined for genetic variability and differentiation at 7 enzyme loci known to be polymorphic in this species. In addiditon,...
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Article
Low content of the natural ocular anti-angiogenic agent pigment epithelium-derived factor (PEDF) in aqueous humor predicts progression of diabetic retinopathy
Retinopathy is the most common microvascular complication of diabetes. Our aim was to address the predictive value of pro-angiogenic and anti-angiogenic markers for progression of retinopathy.
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Chapter
Full Absolute Stereostructures of Natural Products Directly from Crude Extracts: The HPLC-MS/MS-NMR-CD ‘Triad’
This chapter deals with an efficient methodology available in our Center of Excellence, BIOTECmarin: the novel analytical ‘triad’ HPLC-MS/ MS-NMR-CD. By this method, which was, in this complemented form, first...
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Chapter
Sorbicillactone A: a Structurally Unprecedented Bioactive Novel-Type Alkaloid from a Sponge-Derived Fungus
This chapter deals with the discovery of sorbicillactone A, as an illustrative example of the fruitful cooperation within BIOTECmarin — its isolation and chemical characterization, and its biological activitie...
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Article
Stability of perchlorate ions in acid medium: Interaction with iron
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Article
Graphical characterisation of probability distribution tails
The purpose of this paper is to present a graphical method to characterise the nature of a distribution (exponential or algebraic). In the algebraic case, this statistical tool provides an estimation procedur...
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Article
Stability of perchlorate ions in acid medium: Interaction with zinc and aluminium
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Article
Was kosten gefäßchirurgische Operationen? Eine prospektive Kostenanalyse konventioneller und kombiniert endovaskulärer Eingriffe
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Article
Stability of perchlorate ions in acid medium: Interaction with nickel and copper metals