26 Result(s)

Article

Modeling invasive breast cancer: growth factors propel progression of HER2-positive premalignant lesions

The HER2/neu oncogene encodes a receptor-like tyrosine kinase whose overexpression in breast cancer predicts poor prognosis and resistance to conventional therapies. However, the mechanisms underlying aggressi...

C-R Pradeep, A Zeisel, W J Köstler, M Lauriola, J Jacob-Hirsch, B Haibe-Kains… in Oncogene (2012)

Article

Modeling ductal carcinoma in situ: a HER2–Notch3 collaboration enables luminal filling

A large fraction of ductal carcinoma in situ (DCIS), a non-invasive precursor lesion of invasive breast cancer, overexpresses the HER2/neu oncogene. The ducts of DCIS are abnormally filled with cells that evade a...

C-R Pradeep, W J Köstler, M Lauriola, R Z Granit, F Zhang, J Jacob-Hirsch… in Oncogene (2012)

Article

Specific self-antigen-driven immune response in pericardial effusion as an isolated GVHD manifestation

Pericardial effusion and cardiac tamponade have been described as GVHD manifestations in the post transplant period. Direct evidence of GVHD-related TCR or B-cell receptor clones in patients with pericardial e...

A Lev, N Amariglio, Z Spirer, U Katz, B Bielorai, G Rechavi… in Bone Marrow Transplantation (2010)

Article

Interferon-γ-induced neuronal differentiation of human umbilical cord blood-derived progenitors

Human umbilical cord blood (HUCB) provides a source of progenitors for cell therapy. We isolated and characterized an HUCB-derived population of progenitors (HUCBNP), differentiated toward neuronal phenotype b...

H Arien-Zakay, S Lecht, M M Bercu, N Amariglio, G Rechavi, H Galski… in Leukemia (2009)

Article

Cancer cells suppress p53 in adjacent fibroblasts

The p53 tumor suppressor serves as a crucial barrier against cancer development. In tumor cells and their progenitors, p53 suppresses cancer in a cell-autonomous manner. However, p53 also possesses non-cell-au...

J Bar, R Feniger-Barish, N Lukashchuk, H Shaham, N Moskovits, N Goldfinger… in Oncogene (2009)

Article

The CXCR4 antagonist AMD3100 impairs survival of human AML cells and induces their differentiation

The chemokine stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, participate in the retention of acute myeloblastic leukemia (AML) cells within the bone marrow microenvironment and their release in...

S Tavor, M Eisenbach, J Jacob-Hirsch, T Golan, I Petit, K BenZion, S Kay… in Leukemia (2008)

Article

The presence of a single PML-RARA isoform lacking exon 5 in FISH-negative APL samples

O Ashur-Fabian, L Trakhtenbrot, D Dominissini, M Koren-Michowitz, A Nagler… in Leukemia (2008)

Article

High-throughput, sensitive and quantitative assay for the detection of BCR-ABL kinase domain mutations

A Vivante, N Amariglio, M Koren-Michowitz, O Ashur-Fabian, A Nagler, G Rechavi… in Leukemia (2007)

Article

P53 in blind subterranean mole rats – loss-of-function versus gain-of-function activities on newly cloned Spalax target genes

A tumor suppressor gene, p53, controls cellular responses to a variety of stress conditions, including DNA damage and hypoxia, leading to growth arrest and/or apoptosis. Recently, we demonstrated that in blind su...

A Avivi, O Ashur-Fabian, A Joel, L Trakhtenbrot, K Adamsky, I Goldstein… in Oncogene (2007)

Article

Gene expression profiles of AML derived stem cells; similarity to hematopoietic stem cells

Tumors contain a fraction of cancer stem cells that maintain the propagation of the disease. The CD34+CD38− cells, isolated from acute myeloid leukemia (AML), were shown to be enriched leukemic stem cells (LSC...

H Gal, N Amariglio, L Trakhtenbrot, J Jacob-Hirsh, O Margalit, A Avigdor… in Leukemia (2006)

Article

S100A2 gene is a direct transcriptional target of p53 homologues during keratinocyte differentiation

The p53 paralogues p73, p63 and their respective truncated isoforms have been shown to be critical regulators of developmental and differentiation processes. Indeed, both p73- and p63-deficient mice exhibit se...

E Lapi, A Iovino, G Fontemaggi, A R Soliera, S Iacovelli, A Sacchi, G Rechavi… in Oncogene (2006)

Article

The UVB-induced gene expression profile of human epidermis in vivo is different from that of cultured keratinocytes

In order to obtain a comprehensive picture of the molecular events regulating cutaneous photodamage of intact human epidermis, suction blister roofs obtained after a single dose of in vivo ultraviolet (UV)B expos...

C D Enk, J Jacob-Hirsch, H Gal, I Verbovetski, N Amariglio, D Mevorach… in Oncogene (2006)

Article

Parallel induction of ATM-dependent pro- and antiapoptotic signals in response to ionizing radiation in murine lymphoid tissue

The ATM protein kinase, functionally missing in patients with the human genetic disorder ataxia-telangiectasia, is a master regulator of the cellular network induced by DNA double-strand breaks. The ATM gene is a...

S Rashi-Elkeles, R Elkon, N Weizman, C Linhart, N Amariglio, G Sternberg… in Oncogene (2006)

Article

Multilineage hematopoietic engraftment after allogeneic peripheral blood stem cell transplantation without conditioning in SCID patients

Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. B lymphocytes engraft in ...

B Bielorai, L Trakhtenbrot, N Amariglio, R Rothman, U Tabori… in Bone Marrow Transplantation (2004)

Article

Tetraploid myeloid cells in donors of peripheral blood stem cells treated with rhG-CSF

Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is frequently used to mobilize CD34+ cells in healthy donors and patient with malignant diseases prior to peripheral blood stem cell (PBSC) har...

C Kaplinsky, L Trakhtenbrot, I Hardan, M Reichart, M Daniely… in Bone Marrow Transplantation (2003)

Article

B-cell lymphoma develo** in the donor 9 years after donor-origin acute myeloid leukemia post bone marrow transplantation

Donor-cell leukemia post bone marrow transplantation is a rare event. Most of the cases reported to date have developed in cells from an HLA-matched sibling, who had no evidence of malignant disease before or ...

B Bielorai, H J Deeg, M Weintraub, Y Neumann, E Rosner… in Bone Marrow Transplantation (2003)

Article

Chimerism testing and detection of minimal residual disease after allogeneic hematopoietic transplantation using the bioView (Duet™) combined morphological and cytogenetical analysis

Recurrent disease remains a major obstacle to cure after allogeneic transplantation. Various methods have been developed to detect minimal residual disease (MRD) after transplantation to identify patients at r...

A Shimoni, A Nagler, C Kaplinsky, M Reichart, A Avigdor, I Hardan, M Yeshurun… in Leukemia (2002)

Article

CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation

Hemorrhagic cystitis (HC) is a known complication of stem cell transplantation. In contrast to early-onset HC that is usually attributed to cyclophosphamide and occurs within a few days of infusion, late onset...

B Bielorai, LM Shulman, G Rechavi, A Toren in Bone Marrow Transplantation (2001)

Article

The clinical and biological dilemma of preleukemia presenting as aplastic anemia with chromosomal translocation t(4;11)

U Tabori, Y Burstein, R Dvir, G Rechavi, A Toren in Leukemia (2001)