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Article
Hematopoietic stem cell donation: psychological perspectives of pediatric sibling donors and their parents
Allogeneic stem cell transplantation (SCT) is widely used for treatment of various life-threatening pediatric diseases. It is an intensive process that psychologically affects the whole family. Pediatric donor...
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Article
Regression of subependymal giant cell astrocytomas with RAD001 (Everolimus) in tuberous sclerosis complex
Tuberous sclerosis complex (TSC) is a genetic disorder caused by inactivating mutations in the TSC1 or TSC2 genes and characterized by slow-growing tumors in multiple organs. Of the affected individuals, 10% d...
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Article
An outbreak of Burkholderia cenocepacia bacteremia in immunocompromised oncology patients
Burkholderia cepacia is a common environmental bacterium that is resistant to disinfectants, and therefore is often encountered as a hospital-acquired pathogen. We describe an outbreak of B. cenocepacia bacteremi...
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Article
Long-term results of the Israeli National Studies in childhood acute lymphoblastic leukemia: INS 84, 89 and 98
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Article
Multilineage hematopoietic engraftment after allogeneic peripheral blood stem cell transplantation without conditioning in SCID patients
Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. B lymphocytes engraft in ...
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Article
Tetraploid myeloid cells in donors of peripheral blood stem cells treated with rhG-CSF
Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is frequently used to mobilize CD34+ cells in healthy donors and patient with malignant diseases prior to peripheral blood stem cell (PBSC) har...
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Article
B-cell lymphoma develo** in the donor 9 years after donor-origin acute myeloid leukemia post bone marrow transplantation
Donor-cell leukemia post bone marrow transplantation is a rare event. Most of the cases reported to date have developed in cells from an HLA-matched sibling, who had no evidence of malignant disease before or ...
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Article
Solubilization of polyaromatic hydrocarbons by recombinant bioemulsifier AlnA
AlnA is the protein responsible for the emulsifying and solubilizing activity of the Acinetobacter radioresistens KA53 bioemulsifier alasan. AlnA was produced in Escherichia coli, purified to homogeneity and the...
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Article
CMV reactivation induced BK virus-associated late onset hemorrhagic cystitis after peripheral blood stem cell transplantation
Hemorrhagic cystitis (HC) is a known complication of stem cell transplantation. In contrast to early-onset HC that is usually attributed to cyclophosphamide and occurs within a few days of infusion, late onset...
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Article
The clinical and biological dilemma of preleukemia presenting as aplastic anemia with chromosomal translocation t(4;11)
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Article
Successful treatment of invasive aspergillosis in chronic granulomatous disease by granulocyte transfusions followed by peripheral blood stem cell transplantation
Chronic granulomatous disease (CGD) is a primary immunodeficiency disorder characterized by impaired microbial killing and susceptibility to bacterial and fungal infections. Cure of the disease can be achieved...
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Article
Successful human umbilical cord blood stem cell transplantation without conditioning in severe combined immune deficiency
A 2-month-old girl with severe combined immunodeficiency (SCID), presented with mild staphylococcal skin infection, lymphopenia, low T cell number, absence of B cells, high number of NK cells, and a negligible...
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Article
Open AccessA photodynamic pathway to apoptosis and necrosis induced by dimethyl tetrahydroxyhelianthrone and hypericin in leukaemic cells: possible relevance to photodynamic therapy
The mechanism of cell death induction by dimethyl tetrahydroxyhelianthrone (DTHe), a new second-generation photodynamic sensitizer, is analysed in human leukaemic cell lines in comparison with the structurally...
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Article
Early fulminant leukaemia post autologous bone marrow transplantation in non-hodgkin’s lymphoma patients
Although autologous bone marrow transplantation (ABMT) is a curative option for about 50% of the patients with progressive or relapsing Symphomas, considerable concern has been raised recently over the emergin...
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Article
Massive pericardial effusion complicating the course of chronic graft-versus-host disease (cGVHD) in a child with acute lymphoblastic leukemia following allogeneic bone marrow transplantation
The pathogenesis and clinical features of chronic graft-versus-host disease (cGVHD) resemble those of several autoimmune diseases, as evidenced by frequent dermal, hepatic, occular, oral, pulmonary, gastrointe...
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Article
Invasive fungal infections in lymphoma patients receiving immunotherapy following autologous bone marrow transplantation (ABMT)
Invasive fungal infections are quite rare (1–5%) following conventional ABMT for malignant lymphoma. Two high-risk lymphoma patients (one non-Hodgkin’s lymphoma (NHL) and one Hodgkin’s disease) underwent ABMT ...
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Article
The putative role of arylsulfatase in interleukin-2- mediated cytotoxicity and interleukin-7-mediated bactericidal activity of natural killer cells
We have examined the cytolytic and bactericidal activity of resting and cytokine-stimulated natural-killer (NK) cells against K562 and Daudi cell lines and Escherichia coli, respectively. Unstimulated NK cells s...
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Article
Bronchiolitis obliterans presenting as subcutaneous emphysema and pneumomediastinum: A case report
We describe a woman post allogeneic bone marrow transplantation (BMT), who presented to the emergency room with subcutaneous emphysema and pneumomediastinum as the first manifestation of bronchiolitis oblitera...
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Article
The management of pediatric brain tumors in a tertiary center
Between January 1982 and January 1990,120 newly diagnosed pediatric patients were treated at The Chaim Sheba Medical Center. Sixty three (52.5%) tumors arose in the posterior fossa and 57 (47.5%) appeared supr...
