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Article
Application of Scaled Specimens in Evaluating Thermal Fatigue Performance of Cylinder Head
Cylinder head, which has a special geometric structure, is subjected to cyclic thermal loads during engine operation. In such a harsh environment, thermal fatigue is the main failure mode of the cylinder head....
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Article
Malnutrition Increases the Risk of Left Ventricular Remodeling
Malnutrition is associated with increased incidence of heart failure (HF). Left ventricular (LV) remodeling is one of the most important processes in the occurrence and evolution of HF. However, the associatio...
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Article
Taurine Reduces Liver Damage in Non-Alcoholic Fatty Liver Disease Model in Rats by Down-Regulating IL-9 and Tumor Growth Factor TGF-β
The study employed a rat model to examine the effects of taurine (Tau) on prevention and therapy of non-alcoholic fatty liver disease (NAFLD). In model rats maintained on a high-fat diet (HFD), the serum level...
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Article
An experimental study of heat transfer enhancement with winglets inside a tube
The thermal enhancement and pressure drop in a circular tube with radially-arrayed winglet vortex generator (VG) mounted inside at different orientations were experimentally studied. A series of four winglet r...
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Article
Bone marrow mesenchymal stem cells-induced exosomal microRNA-486-3p protects against diabetic retinopathy through TLR4/NF-κB axis repression
Diabetic retinopathy (DR) is a chronic disease causing health and economic burdens on individuals and society. Thus, this study is conducted to figure out the mechanisms of bone marrow mesenchymal stem cells (...
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Article
Open AccessIdentification of risk factors for falls in postmenopausal women: a systematic review and meta-analysis
The purpose of this study was to identify risk factors for falls in postmenopausal women and provide evidence for the primary prevention of falls in postmenopausal women. The protocol for this meta-analysis is...
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Article
DNA methylation aberrancies delineate clinically distinct subsets of colorectal cancer and provide novel targets for epigenetic therapies
Colorectal cancer (CRC) is a worldwide health concern with respect to both incidence and mortality, and as a result, CRC tumorigenesis, progression and metastasis have been heavily studied, especially with res...
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Article
Design, synthesis, and antiproliferative activity assessment of non-ATP-competitive fibroblast growth factor receptor 1 inhibitors
Fibroblast growth factor receptor 1 (FGFR1) is considered a therapeutic target for multiple cancers, including gastric cancer. FGFR1 inhibitors, being ATP competitors, can prevent the kinase domain and the dow...
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Article
Cationic microRNA-delivering nanocarriers for efficient treatment of colon carcinoma in xenograft model
Manipulation of tumor microRNAs (miRNAs) may offer novel avenues for treatment of cancer. However, development of safe, robust, non-viral delivery methods remains a main challenge to obtain the promise of gene th...
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Article
Control of the LiFePO4 electrochemical properties using low-cost iron precursor in a melt process
LiFePO4 was prepared from low-cost iron ore concentrate (containing 4.48 wt.% SiO2 and MgO, CaO and Al2O3 below 0.5 wt.% as contaminant) using a melt synthesis. X-ray diffraction (XRD) refinement associated with ...
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Article
LiFePO4 synthesized via melt synthesis using low-cost iron precursors
LiFePO4/C material has been prepared using fast-melt synthesis method followed by grinding and carbon coating. The low-cost iron ore concentrate (IOC) and purified iron ore concentrate (IOP) were used as iron pre...
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Article
Open AccessMuscle tissue engineering and regeneration through epigenetic reprogramming and scaffold manipulation
Efficiency of cell-based tissue engineering and regenerative medicine has been limited by inadequate cellular responses to injury because of aging and poor controllability of cellular interactions. Since cell ...
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Article
Prognosis of small cell lung cancer patients with diabetes treated with metformin
It has been reported that metformin has an anticancer impact in various solid tumors, but its role in small cell lung cancer (SCLC) remains unclear. This study aimed to investigate the effect of metformin on s...
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Article
Open AccessConcurrent IMRT and weekly cisplatin followed by GDP chemotherapy in newly diagnosed, stage IE to IIE, nasal, extranodal NK/T-Cell lymphoma
On the basis of the benefits of frontline radiation in early-stage, extranodal natural killer (NK)/T-cell lymphoma (ENKTL), we conducted the trial of concurrent chemoradiotherapy (CCRT) followed by three cycle...
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Article
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene
Genes that are differentially expressed between schizophrenia patients and healthy controls may have key roles in the pathogenesis of schizophrenia. We analyzed two large-scale genome-wide expression studies, ...
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Article
Open AccessmiR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer
GRP78, a major endoplasmic reticulum chaperone and signaling regulator, is commonly overexpressed in cancer. Moreover, induction of GRP78 by a variety of anti-cancer drugs, including histone deacetylase inhibi...
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Chapter
Nucleosome Occupancy and Gene Regulation During Tumorigenesis
Nucleosomes are the basic structural units of eukaryotic chromatin. In recent years, it has become evident that nucleosomes and their position, in concert with other epigenetic mechanisms (such as DNA methylat...
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Article
High dose compressive loads attenuate bone mineral loss in humans with spinal cord injury
People with spinal cord injury (SCI) lose bone and muscle integrity after their injury. Early doses of stress, applied through electrically induced muscle contractions, preserved bone density at high-risk site...
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Article
Dual-wavelength Brillouin ring-cavity fiber laser with tunable channel spacing
We experimentally demonstrate a dual-wavelength Brillouin fiber laser configured a pre-amplified Brillouin pump and FBG filter in a ring-cavity. The Brillouin laser can generate 21 Brillouin Stokes with 0.084 ...
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Article
Stable dual-wavelength single-longitudinal-mode ring erbium-doped fiber laser for optical generation of microwave frequency
We demonstrate a simple dual-wavelength ring erbium-doped fiber laser operating in single-longitudinal-mode (SLM) at room temperature. A pair of reflection type short-period fiber Bragg gratings (FBGs), which ...
