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Article
Open AccessSunitinib in combination with gemcitabine for advanced solid tumours: a phase I dose-finding study
This phase I, dose-finding study determined the maximum tolerated dose (MTD), safety, and pharmacokinetics of sunitinib plus gemcitabine in patients with advanced solid tumours.
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Article
Open AccessPre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells
Cellular proliferation, driven by cyclin-dependent kinases (CDKs) and their cyclin partners, is deregulated in cancer. Anti-estrogens, such as tamoxifen, antagonise estrogen-induced ERα transactivation of cyclin ...
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Article
Vertical structure of the field of current velocities in the northwest part of the Black Sea based on the LADCP data for May 2004
The profiles of absolute current velocity obtained by using a lowered acoustic doppler current profiler (LADCP) are presented. In the course of the BSERP-3 expedition, the measurements were carried out in the reg...
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Article
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models
Genetic alterations in the kinase domain of the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) patients are associated with sensitivity to treatment with small molecule tyrosine kin...
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Article
The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272
Mutations in the ERBB2 gene were recently found in approximately 2% of primary non-small cell lung cancer (NSCLC) specimens; however, little is known about the functional consequences and the relevance to respons...
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Article
Using a lowered acoustic Doppler current profiler for measuring current velocities in the Black Sea
The results obtained with the use of a lowered acoustic Doppler current profiler (LADCP) are presented. The use of the LADCP from a vessel was the first in the history of the study of the Black Sea. The measur...
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Article
The effect of velocity veering on sand transport in a shallow sea
This study aims at comparing and contrasting two different models for sand transport by currents in a shallow sea to illustrate the effect of velocity veering. The first model uses the Bailard-type formulation...
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Article
Gravity current down a steeply inclined slope in a rotating fluid
The sinking of dense water down a steep continental slope is studied using laboratory experiments, theoretical analysis and numerical simulation. The experiments were made in a rotating tank containing a solid...
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Chapter and Conference Paper
On the Structure of Wave Fronts in Nonlinear Dissipative Media
Wave fronts are well known to be the regions of space where the properties of motion vary sharply in a certain direction. This means that one of the components of the gradients of density, velocity, stress, etc.,...
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Article
On the structure of wave fronts in nonlinear dissipative media
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Article
Spreading out of a viscous liquid over a horizontal surface
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Article
Method of loading a specimen in testing for fracture toughness