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  1. Article

    Open Access

    Sunitinib in combination with gemcitabine for advanced solid tumours: a phase I dose-finding study

    This phase I, dose-finding study determined the maximum tolerated dose (MTD), safety, and pharmacokinetics of sunitinib plus gemcitabine in patients with advanced solid tumours.

    M D Michaelson, A X Zhu, D P Ryan, D F McDermott, G I Shapiro in British Journal of Cancer (2013)

  2. Article

    Open Access

    Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells

    Cellular proliferation, driven by cyclin-dependent kinases (CDKs) and their cyclin partners, is deregulated in cancer. Anti-estrogens, such as tamoxifen, antagonise estrogen-induced ERα transactivation of cyclin ...

    N Johnson, J Bentley, L-Z Wang, D R Newell, C N Robson in British Journal of Cancer (2010)

  3. No Access

    Article

    Vertical structure of the field of current velocities in the northwest part of the Black Sea based on the LADCP data for May 2004

    The profiles of absolute current velocity obtained by using a lowered acoustic doppler current profiler (LADCP) are presented. In the course of the BSERP-3 expedition, the measurements were carried out in the reg...

    E. M. Lemeshko, A. N. Morozov, S. V. Stanichnyi, L. D. Mee in Physical Oceanography (2008)

  4. No Access

    Article

    BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

    Genetic alterations in the kinase domain of the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) patients are associated with sensitivity to treatment with small molecule tyrosine kin...

    D Li, L Ambrogio, T Shimamura, S Kubo, M Takahashi, L R Chirieac, R F Padera in Oncogene (2008)

  5. No Access

    Article

    The major lung cancer-derived mutants of ERBB2 are oncogenic and are associated with sensitivity to the irreversible EGFR/ERBB2 inhibitor HKI-272

    Mutations in the ERBB2 gene were recently found in approximately 2% of primary non-small cell lung cancer (NSCLC) specimens; however, little is known about the functional consequences and the relevance to respons...

    Y Minami, T Shimamura, K Shah, T LaFramboise, K A Glatt, E Liniker, C L Borgman in Oncogene (2007)

  6. No Access

    Article

    Using a lowered acoustic Doppler current profiler for measuring current velocities in the Black Sea

    The results obtained with the use of a lowered acoustic Doppler current profiler (LADCP) are presented. The use of the LADCP from a vessel was the first in the history of the study of the Black Sea. The measur...

    D. D. Aleinik, G. I. Shapiro, L. D. Mee, E. M. Lemeshko in Oceanology (2007)

  7. No Access

    Article

    The effect of velocity veering on sand transport in a shallow sea

    This study aims at comparing and contrasting two different models for sand transport by currents in a shallow sea to illustrate the effect of velocity veering. The first model uses the Bailard-type formulation...

    G. I. Shapiro, J. van der Molen, H. E. de Swart in Ocean Dynamics (2004)

  8. No Access

    Article

    Gravity current down a steeply inclined slope in a rotating fluid

    The sinking of dense water down a steep continental slope is studied using laboratory experiments, theoretical analysis and numerical simulation. The experiments were made in a rotating tank containing a solid...

    G. I. Shapiro, A. G. Zatsepin in Annales Geophysicae (1997)

  9. No Access

    Chapter and Conference Paper

    On the Structure of Wave Fronts in Nonlinear Dissipative Media

    Wave fronts are well known to be the regions of space where the properties of motion vary sharply in a certain direction. This means that one of the components of the gradients of density, velocity, stress, etc.,...

    G. I. Barenblatt, M. Ya. Ivanov in The Breadth and Depth of Continuum Mechani… (1986)

  10. No Access

    Article

    On the structure of wave fronts in nonlinear dissipative media

    G. I. Barenblatt, M. Ya. Ivanov in Archive for Rational Mechanics and Analysis (1985)

  11. No Access

    Article

    Spreading out of a viscous liquid over a horizontal surface

    G. I. Shapiro in Journal of Applied Mechanics and Technical Physics (1983)

  12. No Access

    Article

    Method of loading a specimen in testing for fracture toughness

    G. I. Shapiro, V. I. Yagust in Soviet materials science : a transl. of Fi… (1977)