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Article
Structure and Photocatalytic Properties of a 3D Zinc(II) Triazolate Coordination Polymer Combining Hydroxyl and Formate Anions as the Auxiliary Coligands
A new 3D zinc coordination polymer, namely {[Zn4(dmtz)3(OH)3(HCOO)](NO3)}n (1, Hdmtz = 3,5- dimethyl-1,2,4-triazole), is hydrothermally synthesized and structurally characterized by elemental analyses, IR spectro...
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Article
Open AccessPhase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer
Current data suggest that platinum-based combination therapy is the standard first-line treatment for biliary tract cancer. EGFR inhibition has proven beneficial across a number of gastrointestinal malignancie...
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Article
Open AccessSunitinib in combination with gemcitabine for advanced solid tumours: a phase I dose-finding study
This phase I, dose-finding study determined the maximum tolerated dose (MTD), safety, and pharmacokinetics of sunitinib plus gemcitabine in patients with advanced solid tumours.
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Article
The role of signaling pathways in the development and treatment of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a multifaceted molecular pathogenesis. Current evidence indicates that during hepatocarcinogenesis, two main pathogenic...
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Article
Phase I trial of oral MAC-321 in subjects with advanced malignant solid tumors
MAC-321 is a novel taxane that has demonstrated exceptional activity in human xenograft models when administered intravenously and orally. Preclinical studies of MAC-321 have shown antitumor activity in MDR-ex...
