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Open AccessA paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice
Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dieta...
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Open AccessPhase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer
Current data suggest that platinum-based combination therapy is the standard first-line treatment for biliary tract cancer. EGFR inhibition has proven beneficial across a number of gastrointestinal malignancie...
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Open AccessMechanisms of RNA-induced toxicity in CAG repeat disorders
Several inherited neurodegenerative disorders are caused by CAG trinucleotide repeat expansions, which can be located either in the coding region or in the untranslated region (UTR) of the respective genes. Po...
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Open AccessSunitinib in combination with gemcitabine for advanced solid tumours: a phase I dose-finding study
This phase I, dose-finding study determined the maximum tolerated dose (MTD), safety, and pharmacokinetics of sunitinib plus gemcitabine in patients with advanced solid tumours.
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Open AccessOxaliplatin-induced Evan’s syndrome
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Practical implementation of the bacterial oxidation process of refractory gold ores
The effective treatment of refractory arsenopyritic gold ore is of growing significance, especially in countries such as Australia where many of the more readily accessible oxide deposits are approaching deple...
