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Article
Open AccessRisk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy: international individual patient data pooled analysis
To investigate the frequency, time-course and predictors of intracerebral haemorrhage (ICH), recurrent convexity subarachnoid haemorrhage (cSAH), and ischemic stroke after cSAH associated with cerebral amyloid...
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Article
Open AccessRelationship between stroke etiology and collateral status in anterior circulation large vessel occlusion
Clinical outcome after mechanical thrombectomy (MT) for large vessel occlusion (LVO) stroke is influenced by the intracerebral collateral status. We tested the hypothesis that patients with preexisting ipsilat...
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Article
Open AccessPredictors of Lesion Cavitation After Recent Small Subcortical Stroke
Morphologic evolution of recent small subcortical infarcts (RSSI) ranges from lesion disappearance to lacune formation and the reasons for this variability are still poorly understood. We hypothesized that dif...
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Article
Open AccessSingle mean arterial blood pressure drops during stroke thrombectomy under general anaesthesia are associated with poor outcome
We examined the influence of periprocedural blood pressure (BP), especially critical BP drops, on 3-month functional outcome in stroke patients undergoing mechanical thrombectomy (MT) under general anaesthesia...
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Article
Open AccessPostural hemodynamic parameters in older persons have a seasonal dependency
It is known that blood pressure regulation differs seasonally. It is unknown, however, how the cardiovascular system in patients with a stroke reacts to postural changes in different seasons. The aim was there...
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Article
Open AccessSerum neurofilament light levels in normal aging and their association with morphologic brain changes
Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also in serum, which allows for repeated assessments. There is still limited knowled...
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Article
Open AccessMorphological MRI phenotypes of multiple sclerosis differ in resting-state brain function
We aimed to assess differences in resting-state functional connectivity (FC) between distinct morphological MRI-phenotypes in multiple sclerosis (MS). Out of 180 MS patients, we identified those with high T2-h...
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Article
Open AccessEarly renal dysfunction and fibroblast growth factor-23 in patients with small vessel disease-related stroke
Interactions between cerebral small vessel disease (CSVD) and renal dysfunction (RD) have been reported, but previous studies were mostly retrospective and limited to measurements of estimated glomerular filtr...
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Article
Neurofilaments as biomarkers in neurological disorders
Neuroaxonal damage is the pathological substrate of permanent disability in various neurological disorders. Reliable quantification and longitudinal follow-up of such damage are important for assessing disease...
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Article
Erratum: The current role of MRI in differentiating multiple sclerosis from its imaging mimics
Nature Reviews Neurology 14, 199–213 (2018) In the version of this article originally published online, the heading of the third column in Table 1 was “Percentage of lesions that meet criteria”. This heading s...
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The current role of MRI in differentiating multiple sclerosis from its imaging mimics
MRI is crucial in the diagnosis of multiple sclerosis (MS), revealing the dissemination in space and time of white matter lesions (WMLs) and hel** to rule ou...
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Open AccessImpact of small vessel disease in the brain on gait and balance
Gait and balance impairment is highly prevalent in older people. We aimed to assess whether and how single markers of small vessel disease (SVD) or a combination thereof explain gait and balance function in th...
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Article
Frequency of MELAS main mutation in a phenotype-targeted young ischemic stroke patient population
Mitochondrial diseases, predominantly mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), may occasionally underlie or coincide with ischemic stroke (IS) in young and middle-age...
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Article
Poor short-term outcome in patients with ischaemic stroke and active cancer
Stroke risk is increased in cancer patients and cancer activity has been claimed to play a role in the development of ischaemic stroke (IS). We wanted to further test these assumptions and to explore the impac...
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Nonconventional MRI and microstructural cerebral changes in multiple sclerosis
MRI scanner performance and the development of multiple advanced techniques have progressed to an extent that nonconventional MRI can now be used in clinical r...
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Cerebral small vessel disease, cognitive reserve and cognitive dysfunction
The concept of cognitive reserve describes differences between individuals in the ability to compensate age-related brain changes or pathology as a result of greater intellectual enrichment. Cerebral small ves...
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Open AccessMAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process
The use of MRI in patients with multiple sclerosis (MS) is commonplace in clinical settings. However, the precise implementation of MRI in the diagnosis of MS is highly variable, which is problematic in the co...
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Article
Neurological abnormalities predict disability: the LADIS (Leukoaraiosis And DISability) study
To investigate the role of neurological abnormalities and magnetic resonance imaging (MRI) lesions in predicting global functional decline in a cohort of initially independent-living elderly subjects. The Leuk...
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Erratum to: Atypical idiopathic inflammatory demyelinating lesions: prognostic implications and relation to multiple sclerosis
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Open AccessLessons from everyday stroke care for clinical research and vice versa: comparison of a comprehensive and a research population of young stroke patients
Translating knowledge derived from medical research into the clinical setting is dependent on the representativeness of included patients. Therefore we compared baseline data of patients included in a recent l...
