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Article
Open AccessInterpretable brain disease classification and relevance-guided deep learning
Deep neural networks are increasingly used for neurological disease classification by MRI, but the networks’ decisions are not easily interpretable by humans. Heat map** by deep Taylor decomposition revealed...
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Article
Open AccessIncidental findings of typical iNPH imaging signs in asymptomatic subjects with subclinical cognitive decline
The etiology of idiopathic normal pressure hydrocephalus (iNPH) remains unclear. Little is known about the pre-symptomatic stage. This study aimed to investigate the association of neuropsychological data with...
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Article
Open AccessGenetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults
Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations o...
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Article
Open AccessSerum neurofilament light levels in normal aging and their association with morphologic brain changes
Neurofilament light (NfL) protein is a marker of neuro-axonal damage and can be measured not only in cerebrospinal fluid but also in serum, which allows for repeated assessments. There is still limited knowled...
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Article
Open AccessNovel genetic loci associated with hippocampal volume
The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are foun...
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Article
Novel genetic loci underlying human intracranial volume identified through genome-wide association
In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cogni...
