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  1. No Access

    Chapter

    Discriminative Stimulus Properties of Hallucinogens: Behavioral Assay of Drug Action

    In this chapter we will review existing literature on the discriminative stimulus properties of several drugs which are often classified as hallucinogens. At the same time we ‘will try to answer several questi...

    Donald M. Kuhn, Francis J. White… in Discriminative Stimulus Properties of Drugs (1977)

  2. No Access

    Article

    A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine

    Rats were trained to discriminate fenfluramine (1.0 mg/kg) from saline in a two-lever drug discrimination task. The dose-response curve for this discrimination was orderly with an ED50 of about one-half of the tr...

    Francis J. White, James B. Appel in Psychopharmacology (1981)

  3. No Access

    Article

    Training dose as a factor in LSD-saline discrimination

    To assess the effects of training dose on the discriminative stimulus properties of LSD, groups of rats (eight/group) were trained to discriminate each of three doses of LSD (0.02, 0.08 or 0.32 mg/kg) from sal...

    Francis J. White, James B. Appel in Psychopharmacology (1982)

  4. No Access

    Article

    Antagonism of a behavioral effect of LSD and lisuride in the cat

    These experiments investigated the role of serotonin (5-HT) and dopamine (DA) receptors in the limb-flick (LF) response elicited by the hallucinogenic ergot LSD and its nonhallucinogenic structural congener li...

    Francis J. White, Alice M. Holohean, James B. Appel in Psychopharmacology (1983)

  5. No Access

    Article

    Parametric and pharmacological analyses of the enhanced grooming response elicited by the D1 dopamine receptor agonist SKF 38393 in the rat

    The present report investigated several parametric and pharmacological aspects of the enhanced self-grooming behavior of rats following systemic administration of the selective D1 dopamine (DA) receptor agonist S...

    Stephen R. Wachtel, Richard J. Brooderson, Francis J. White in Psychopharmacology (1992)

  6. No Access

    Article

    Effects of the AMPA receptor antagonist NBQX on the development and expression of behavioral sensitization to cocaine and amphetamine

     We examined the effect of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX), an antagonist of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of glutamate receptor, on the deve...

    Yong Li, A. John Vartanian, Francis J. White, Chang-Jiang Xue… in Psychopharmacology (1997)

  7. No Access

    Article

    Cocaine and the serotonin saga

    To devise ways to treat cocaine addiction, the cellular mechanisms behind that addiction have to be understood. One study goes some way to doing this by generating mice that lack the serotonin-1B receptor. Bef...

    Francis J. White in Nature (1998)

  8. No Access

    Article

    Nicotine addiction and the lure of reward

    Withdrawal from chronic nicotine exposure decreases the activity of the brain reward pathway in a manner similar to other addictive drugs.

    Francis J. White in Nature Medicine (1998)

  9. No Access

    Article

    Loss of autoreceptor functions in mice lacking the dopamine transporter

    Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may be a compo...

    Sara R. Jones, Raul R. Gainetdinov, **u-Ti Hu, Donald C. Cooper… in Nature Neuroscience (1999)

  10. No Access

    Article

    The vicious cyclin of addiction

    Drug addiction is a major therapeutic challenge, as little is known about the changes in neural function that occur during its development. DNA microarray analysis has revealed a new component in the dopamine-...

    Francis J. White, Donald C. Cooper in Nature Medicine (2001)

  11. No Access

    Article

    Dopamine receptors get a boost

    A protein that controls the growth and survival of neurons is now shown to have another task: boosting the expression of a molecule that allows neurons to respond to the neurotransmitter dopamine.

    Francis J. White in Nature (2001)

  12. No Access

    Article

    Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior

    Withdrawal from non-contingent exposure to psychostimulants increases the activity of midbrain dopamine cells and impairs the function of impulse-regulating dopamine autoreceptors. It is unclear whether these ...

    Michela Marinelli, Donald C. Cooper, Lorinda K. Baker… in Psychopharmacology (2003)

  13. Article

    Erratum to: Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior

    Michela Marinelli, Donald C. Cooper, Lorinda K. Baker… in Psychopharmacology (2003)

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  14. Article

    Repeated Cocaine Administration Decreases Calcineurin (PP2B) but Enhances DARPP-32 Modulation of Sodium Currents in Rat Nucleus Accumbens Neurons

    Our previous studies have demonstrated that repeated cocaine (COC) administration reduces voltage-sensitive sodium and calcium currents (INa or VSSCs and ICa or VSCCs, respectively) in medium spiny nucleus accumb...

    **u-Ti Hu, Kerstin Ford, Francis J White in Neuropsychopharmacology (2005)

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  15. No Access

    Article

    Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity

    Individual prefrontal cortex neurons can exhibit persistent activity during a delay between a cue and a behavioral response. Here the authors report on an mGluR5-mediated depolarization that underlies persiste...

    Kyriaki Sidiropoulou, Fang-Min Lu, Melissa A Fowler, Rui **ao… in Nature Neuroscience (2009)