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Article
Methylphenidate with or without fluoxetine triggers reinstatement of cocaine seeking behavior in rats
Methylphenidate (MP) is commonly prescribed to treat attention-deficit hyperactivity disorder (ADHD). MP is also taken for non-medical purposes as a recreational drug or “cognitive enhancer”. Combined exposure...
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Article
Reduced sensitivity to reinforcement in adolescent compared to adult Sprague-Dawley rats of both sexes
Adolescence is a period of considerable development of brain and behavior and is the time during which most drug use is initiated.
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Article
Fos After Single and Repeated Self-Administration of Cocaine and Saline in the Rat: Emphasis on the Basal Forebrain and Recalibration of Expression
The effects of addictive psychostimulant drugs on the brain change over repeated administrations. We evaluated a large sample of brain structures, particularly ones comprising basal forebrain macrosystems, and...
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Article
Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking
The glucocorticoid receptor is a transcription factor that mediates adaptation to stress. The authors show that selective glucocorticoid receptor deletion in postsynaptic dopamine receptor 1a–expressing neuron...
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Article
Prominent Activation of Brainstem and Pallidal Afferents of the Ventral Tegmental Area by Cocaine
Blockade of monoamine transporters by cocaine should not necessarily lead to certain observed consequences of cocaine administration, including increased firing of ventral mesencephalic dopamine (DA) neurons a...
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Article
Formation of accumbens GluR2-lacking AMPA receptors mediates incubation of cocaine craving
Relapse to cocaine use after abstinence is often induced by drug-associated cues, but what mediates this reactivity of neurons to these cues is not fully understood. Cocaine-seeking depends on activation of gl...
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Article
Erratum to: Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior
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Article
The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat
Acute 1-day food deprivation stress reinstates heroin seeking in rats, but the generality of this effect to other drugs, and its underlying mechanisms, are largely unknown. Here we studied whether food depriv...
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Article
Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior
Withdrawal from non-contingent exposure to psychostimulants increases the activity of midbrain dopamine cells and impairs the function of impulse-regulating dopamine autoreceptors. It is unclear whether these ...
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Chapter
Influence of Environmental and Hormonal Factors in Sensitivity to Psychostimulants
This review will analyze the interactions among glucocorticoid hormones, life events, and behavioral effects of pyschostimulant drugs. After an introductory section on the physiology of the hypothalamus—pituit...
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Article
Sensitization to the motor effects of contingent infusions of heroin but not of κ agonist RU 51599
It has been postulated that behavioral sensitization could reflect drug-induced changes that are central to the development of drug abuse; however, it is still unknown whether behavioral sensitization can ari...
