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Article
Dopamine modulates an mGluR5-mediated depolarization underlying prefrontal persistent activity
Individual prefrontal cortex neurons can exhibit persistent activity during a delay between a cue and a behavioral response. Here the authors report on an mGluR5-mediated depolarization that underlies persiste...
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Article
Repeated Cocaine Administration Decreases Calcineurin (PP2B) but Enhances DARPP-32 Modulation of Sodium Currents in Rat Nucleus Accumbens Neurons
Our previous studies have demonstrated that repeated cocaine (COC) administration reduces voltage-sensitive sodium and calcium currents (INa or VSSCs and ICa or VSCCs, respectively) in medium spiny nucleus accumb...
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Article
Erratum to: Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior
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Article
Impulse activity of midbrain dopamine neurons modulates drug-seeking behavior
Withdrawal from non-contingent exposure to psychostimulants increases the activity of midbrain dopamine cells and impairs the function of impulse-regulating dopamine autoreceptors. It is unclear whether these ...
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Article
Dopamine receptors get a boost
A protein that controls the growth and survival of neurons is now shown to have another task: boosting the expression of a molecule that allows neurons to respond to the neurotransmitter dopamine.
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Article
The vicious cyclin of addiction
Drug addiction is a major therapeutic challenge, as little is known about the changes in neural function that occur during its development. DNA microarray analysis has revealed a new component in the dopamine-...
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Article
Loss of autoreceptor functions in mice lacking the dopamine transporter
Autoreceptors provide an important inhibitory feedback mechanism for dopamine neurons by altering neuronal functions in response to changes in extracellular levels of dopamine. Elevated dopamine may be a compo...
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Article
Nicotine addiction and the lure of reward
Withdrawal from chronic nicotine exposure decreases the activity of the brain reward pathway in a manner similar to other addictive drugs.
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Article
Cocaine and the serotonin saga
To devise ways to treat cocaine addiction, the cellular mechanisms behind that addiction have to be understood. One study goes some way to doing this by generating mice that lack the serotonin-1B receptor. Bef...
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Article
Effects of the AMPA receptor antagonist NBQX on the development and expression of behavioral sensitization to cocaine and amphetamine
We examined the effect of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX), an antagonist of the α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) subtype of glutamate receptor, on the deve...
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Article
Parametric and pharmacological analyses of the enhanced grooming response elicited by the D1 dopamine receptor agonist SKF 38393 in the rat
The present report investigated several parametric and pharmacological aspects of the enhanced self-grooming behavior of rats following systemic administration of the selective D1 dopamine (DA) receptor agonist S...
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Article
Antagonism of a behavioral effect of LSD and lisuride in the cat
These experiments investigated the role of serotonin (5-HT) and dopamine (DA) receptors in the limb-flick (LF) response elicited by the hallucinogenic ergot LSD and its nonhallucinogenic structural congener li...
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Article
Training dose as a factor in LSD-saline discrimination
To assess the effects of training dose on the discriminative stimulus properties of LSD, groups of rats (eight/group) were trained to discriminate each of three doses of LSD (0.02, 0.08 or 0.32 mg/kg) from sal...
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Article
A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine
Rats were trained to discriminate fenfluramine (1.0 mg/kg) from saline in a two-lever drug discrimination task. The dose-response curve for this discrimination was orderly with an ED50 of about one-half of the tr...
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Chapter
Discriminative Stimulus Properties of Hallucinogens: Behavioral Assay of Drug Action
In this chapter we will review existing literature on the discriminative stimulus properties of several drugs which are often classified as hallucinogens. At the same time we ‘will try to answer several questi...