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Article
Early preclinical studies of discriminable sedative and hallucinogenic drug effects
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Article
Early preclinical studies of discriminable sedative and hallucinogenic drug effects
One important technique in behavioral pharmacology is to train laboratory animals to discriminate between a psychoactive drug effect and a nondrug condition. Tests with different drugs have identified several ...
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Article
Differentiation between the stimulus effects of (+)-lysergic acid diethylamide and lisuride using a three-choice, drug discrimination procedure
The discriminative stimulus properties of (+)-lysergic acid diethylamide (LSD) and lisuride hydrogen maleate (LHM), were compared in a three-choice, water reinforced (FR 20) situation in which rats were requir...
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Article
Effects of stimulation and blockade of dopamine receptor subtypes on the discriminative stimulus properties of cocaine
The involvement of dopamine (DA) receptor subtypes in the behavioral effects of CNS stimulants was studied in rats trained to discriminate occaine from saline. In substitution tests, the stimulus effects of 10...
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Article
Effects of repeated administration of the monoamine oxidase inhibitor phenelzine on the discriminability of d-lysergic acid diethylamide (LSD) and 1-(m-trifluoromethylphenyl) piperazine (TFMPP)
Rats trained to discriminate d-lysergic acid diethylamide (LSD; 0.08 mg/kg) or 1-(m-trifluoromethylphenyl) piperazine (TFMPP; 0.8 mg/kg) were treated with the monoamine oxidase inhibitor (MAOI) phenelzine (10 mg/...
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Article
The effect of drugs on the acquisition of stimulus control in a conditioned suppression procedure
Rats were trained to press a lever under a variable-interval (VI) schedule of water reinforcement. After stable responding had developed, a 4.5-KHz tone (CS) was conditioned classically to a 2.5-mA electric sh...
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Article
The effects of drugs on the discrimination of color following a variable delay period: A signal detection analysis
Six pigeons were trained in a chamber with three response keys. Following an observing response on the center key, either colored or noncolored (white) lights were projected on that key. A second center key ob...
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Article
Antagonism of a behavioral effect of LSD and lisuride in the cat
These experiments investigated the role of serotonin (5-HT) and dopamine (DA) receptors in the limb-flick (LF) response elicited by the hallucinogenic ergot LSD and its nonhallucinogenic structural congener li...
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Article
Psilocybin as a discriminative stimulus: Lack of specificity in an animal behavior model for ‘hallucinogens’
Fifteen rats were trained to discriminate between the tryptamine hallucinogen psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine; 1.0 mg/kg) and saline in a two-lever choice task. Dose-response and time-response ...
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Article
Training dose as a factor in LSD-saline discrimination
To assess the effects of training dose on the discriminative stimulus properties of LSD, groups of rats (eight/group) were trained to discriminate each of three doses of LSD (0.02, 0.08 or 0.32 mg/kg) from sal...
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Article
A neuropharmacological analysis of the discriminative stimulus properties of fenfluramine
Rats were trained to discriminate fenfluramine (1.0 mg/kg) from saline in a two-lever drug discrimination task. The dose-response curve for this discrimination was orderly with an ED50 of about one-half of the tr...
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Article
Effects of pentazocine and other opiates on shock detection in the rat: Involvement of opiate and dopamine receptors
The hypothesis that the antinociceptive effects of pentazocine, a mixed agonist-antagonist opiate of the benzomorphan class, are mediated by a dual opiate-dopaminergic mechanism was tested using a two-choice p...
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Article
Drugs and the discrimination of duration
The effects of lysergic acid diethylamide (LSD), d-amphetamine (AMP), chlorpromazine (CPZ), and the most active isomer of marihuana (Δ9-THC) on timing behavior were analyzed with a two-choice, discrete trial proc...
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Article
Drug effects on the performance of pigeons under a negative automaintenance schedule
Pigeons were exposed to a negative automaintenance schedule in which food was delivered following brief key illumination only if the illuminated key was not contacted; contact of the lighted key prevented food...
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Article
An analysis of some perceptual effects of morphine, chlorpromazine, and LSD
Male albino rats were trained to detect either a pure tone or a weak footshock embedded in white noise by utilizing a discrete-trial two-choice, successive discrimination procedure. The effects of morphine, ch...
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Article
An APL program for calculating pairwise and nonpairwise a posteriori tests on means
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Article
Effects of morphine and chloropromazine on the detection of shock
A discrete-trial, two-choice, ‘yes-no’ procedure was used to determine the extent to which the perceptual effects of compounds such as morphine and chlorpromazine (CPZ) can be attributed to drug-induced change...
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Chapter
Discriminative Stimulus Properties of Hallucinogens: Behavioral Assay of Drug Action
In this chapter we will review existing literature on the discriminative stimulus properties of several drugs which are often classified as hallucinogens. At the same time we ‘will try to answer several questi...
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Article
Effects of LSD on auditory perception: A signal detection analysis
The effects of LSD on perceptual behavior were analyzed with a signal detection procedure. This procedure is designed so that at least two of the parameters of a discrimination can be examined. The parameters ...
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Article
A behavioral and pharmacological analysis of some discriminable properties of d-LSD in rats
d-LSD was employed as a discriminative stimulus in a two-lever, freechoice procedure involving water reinforcement with rats. The results indicated that 1. doses of 0.02-0.04 mg/kg of d-LSD were at the “thresh...
