11 Result(s)
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Francesco A. Aprile
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Article
Open AccessA single-domain antibody detects and neutralises toxic Aβ42 oligomers in the Alzheimer’s disease CSF
Amyloid-β42 (Aβ42) aggregation consists of a complex chain of nucleation events producing soluble oligomeric intermediates, which are considered the major neurotoxic agents in Alzheimer’s disease (AD). Cerebral l...
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Open AccessThe ALS/FTD-related C9orf72 hexanucleotide repeat expansion forms RNA condensates through multimolecular G-quadruplexes
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases that exist on a clinico-pathogenetic spectrum, designated ALS/FTD. The most common genetic cause of ALS/FTD ...
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Open AccessGalectin-3 shapes toxic alpha-synuclein strains in Parkinson’s disease
Parkinson’s Disease (PD) is a neurodegenerative and progressive disorder characterised by intracytoplasmic inclusions called Lewy bodies (LB) and degeneration of dopaminergic neurons in the substantia nigra (S...
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Open AccessA rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease
Bicyclic peptides have great therapeutic potential since they can bridge the gap between small molecules and antibodies by combining a low molecular weight of about 2 kDa with an antibody-like binding specific...
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Open AccessC. elegans expressing D76N β2-microglobulin: a model for in vivo screening of drug candidates targeting amyloidosis
The availability of a genetic model organism with which to study key molecular events underlying amyloidogenesis is crucial for elucidating the mechanism of the disease and the exploration of new therapeutic a...
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Open AccessSoluble aggregates present in cerebrospinal fluid change in size and mechanism of toxicity during Alzheimer’s disease progression
Soluble aggregates of amyloid-β (Aβ) have been associated with neuronal and synaptic loss in Alzheimer’s disease (AD). However, despite significant recent progress, the mechanisms by which these aggregated spe...
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Open AccessDifferent soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures of aggregate populations that are closely linked to neurodegenerative conditions, such as Alzheimer’s disease. Here...
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Open AccessAuthor Correction: The molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessDelivery of Native Proteins into C. elegans Using a Transduction Protocol Based on Lipid Vesicles
The nematode worm Caenorhabditis elegans (C. elegans) is a versatile and widely used animal model for in vivo studies of a broad range of human diseases, in particular for understanding their genetic origins and ...
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Open AccessMethods of probing the interactions between small molecules and disordered proteins
It is generally recognized that a large fraction of the human proteome is made up of proteins that remain disordered in their native states. Despite the fact that such proteins play key biological roles and ar...
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Open AccessThe molecular chaperones DNAJB6 and Hsp70 cooperate to suppress α-synuclein aggregation
A major hallmark of Parkinson’s disease (PD) is the presence of Lewy bodies (LBs) in certain neuronal tissues. LBs are protein-rich inclusions, in which α-synuclein (α-syn) is the most abundant protein. Since ...
