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Article
Open AccessScreening of small molecules using the inhibition of oligomer formation in α-synuclein aggregation as a selection parameter
The aggregation of α-synuclein is a central event in Parkinsons’s disease and related synucleinopathies. Since pharmacologically targeting this process, however, has not yet resulted in approved disease-modify...
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Article
Direct measurement of lipid membrane disruption connects kinetics and toxicity of Aβ42 aggregation
The formation of amyloid deposits in human tissues is a defining feature of more than 50 medical disorders, including Alzheimer’s disease. Strong genetic and histological evidence links these conditions to the...
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Article
Open AccessDifferent soluble aggregates of Aβ42 can give rise to cellular toxicity through different mechanisms
Protein aggregation is a complex process resulting in the formation of heterogeneous mixtures of aggregate populations that are closely linked to neurodegenerative conditions, such as Alzheimer’s disease. Here...
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Article
Open Accessβ-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces
α-Synuclein is an intrinsically disordered protein that is associated with the pathogenesis of Parkinson’s disease through the processes involved in the formation of amyloid fibrils. α and β-synuclein are homolog...
