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Article

A rationally designed bicyclic peptide remodels Aβ42 aggregation in vitro and reduces its toxicity in a worm model of Alzheimer’s disease

Bicyclic peptides have great therapeutic potential since they can bridge the gap between small molecules and antibodies by combining a low molecular weight of about 2 kDa with an antibody-like binding specific...

Tatsuya Ikenoue, Francesco A. Aprile, Pietro Sormanni… in Scientific Reports (2020)