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Regulating the expression of therapeutic transgenes by controlled intake of dietary essential amino acids

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    Open Access

    GCN2 contributes to mTORC1 inhibition by leucine deprivation through an ATF4 independent mechanism

    It is well known that the GCN2 and mTORC1 signaling pathways are regulated by amino acids and share common functions, in particular the control of translation. The regulation of GCN2 activity by amino acid ava...

    Julien Averous, Sarah Lambert-Langlais, Florent Mesclon… in Scientific Reports (2016)

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