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Open AccessCorrection: Inhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells
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Open AccessInhibition of the AURKA/YAP1 axis is a promising therapeutic option for overcoming cetuximab resistance in colorectal cancer stem cells
Primary resistance to anti-EGFR therapies affects 40% of metastatic colorectal cancer patients harbouring wild-type RAS/RAF. YAP1 activation is associated with this resistance, prompting an investigation into AUR...
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Open AccessComprehensive genomic profiling on metastatic Melanoma: results from a network screening from 7 Italian Cancer Centres
The current therapeutic algorithm for Advanced Stage Melanoma comprises of alternating lines of Targeted and Immuno-therapy, mostly via Immune-Checkpoint blockade. While Comprehensive Genomic Profiling of soli...
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Open AccessMulti-label transcriptional classification of colorectal cancer reflects tumor cell population heterogeneity
Transcriptional classification has been used to stratify colorectal cancer (CRC) into molecular subtypes with distinct biological and clinical features. However, it is not clear whether such subtypes represent...
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Open AccessThe neuronal protein Neuroligin 1 promotes colorectal cancer progression by modulating the APC/β-catenin pathway
Colorectal cancer (CRC) remains largely incurable when diagnosed at the metastatic stage. Despite some advances in precision medicine for this disease in recent years, new molecular targets, as well as prognos...
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Open AccessA non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine
Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about how metabolic reprogramming contributes to early stages of transformation. Here, we show that the histone deacetylas...
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Open AccessThe EurOPDX Data Portal: an open platform for patient-derived cancer xenograft data sharing and visualization
Patient-derived xenografts (PDX) mice models play an important role in preclinical trials and personalized medicine. Sharing data on the models is highly valuable for numerous reasons – ethical, economical, re...
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Open AccessAuthor Correction: Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
A Correction to this paper has been published: https://doi.org/10.1038/s41588-021-00811-4.
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Open AccessConservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts
Patient-derived xenografts (PDXs) are resected human tumors engrafted into mice for preclinical studies and therapeutic testing. It has been proposed that the mouse host affects tumor evolution during PDX engr...
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Article
Associations between hypovitaminosis D and COVID-19: a narrative review
In the search for factors affecting incidence and lethality of the current COVID-19 pandemic, recent association studies explored the possible role of vitamin D deficiency. Altogether, these studies, in most c...
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Open AccessMachine learning for RNA sequencing-based intrinsic subty** of breast cancer
Stratification of breast cancer (BC) into molecular subtypes by multigene expression assays is of demonstrated clinical utility. In principle, global RNA-sequencing (RNA-seq) should enable reconstructing exist...
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Genomics in Pseudomyxoma Peritonei
Pseudomyxoma peritonei (PMP) syndrome from appendiceal mucinous tumors generically shows a favorable biologic behavior. Cytoreductive surgery plus Hyperthermic IntraPEritoneal Chemotherapy (CRS + HIPEC) is con...
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Open AccessEvolving neoantigen profiles in colorectal cancers with DNA repair defects
Neoantigens that arise as a consequence of tumor-specific mutations can be recognized by T lymphocytes leading to effective immune surveillance. In colorectal cancer (CRC) and other tumor types, a high number ...
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Erratum: Interrogating open issues in cancer medicine with patient-derived xenografts
Nature Reviews Cancer 17, 254–268 (2017) In the online html version of this article, Joan Seoane's affiliations were not correct. He is also a member of the EurOPDX Consortium and is at the Vall d'Hebron Insti...
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Open AccessSelective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer
Stromal content heavily impacts the transcriptional classification of colorectal cancer (CRC), with clinical and biological implications. Lineage-dependent stromal transcriptional components could therefore do...
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Interrogating open issues in cancer precision medicine with patient-derived xenografts
This Opinion article discusses progress and challenges in using patient-derived xenograft (PDX) models in cancer precision medicine. It is primarily co-authored by members of the EurOPDX Consortium and as such...
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Correction: Corrigendum: Stromal contribution to the colorectal cancer transcriptome
Nat. Genet. 47, 312–319 (2015); published online 23 February 2015; corrected after print 29 August 2016 In the version of this article initially published, an affiliation for author Zsolt Fekete was incorrectl...
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Open AccessDetection of gene communities in multi-networks reveals cancer drivers
We propose a new multi-network-based strategy to integrate different layers of genomic information and use them in a coordinate way to identify driving cancer genes. The multi-networks that we consider combine...
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Open AccessMicroRNA–mRNA interactions underlying colorectal cancer molecular subtypes
Colorectal cancer (CRC) transcriptional subtypes have been recently identified by gene expression profiling. Here we describe an analytical pipeline, microRNA master regulator analysis (MMRA), developed to sea...
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Open AccessA diphtheria toxin resistance marker for in vitro and in vivo selection of stably transduced human cells
We developed a selectable marker rendering human cells resistant to Diphtheria Toxin (DT). The marker (DTR) consists of a primary microRNA sequence engineered to downregulate the ubiquitous DPH2 gene, a key enzym...
