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Article
Open AccessWNT signalling control by KDM5C during development affects cognition
Although KDM5C is one of the most frequently mutated genes in X-linked intellectual disability1, the exact mechanisms that lead to cognitive impairment remain unknown. Here we use human patient-derived induced pl...
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Article
Open AccessSRSF3 maintains transcriptome integrity in oocytes by regulation of alternative splicing and transposable elements
The RNA-binding protein SRSF3 (also known as SRp20) has critical roles in the regulation of pre-mRNA splicing. Zygotic knockout of Srsf3 results in embryo arrest at the blastocyst stage. However, SRSF3 is also pr...
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Article
Open AccessEnriching Traditional Protein-protein Interaction Networks with Alternative Conformations of Proteins
Traditional Protein-Protein Interaction (PPI) networks, which use a node and edge representation, lack some valuable information about the mechanistic details of biological processes. Map** protein structure...
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Article
Open AccessHistone modifications and p53 binding poise the p21 promoter for activation in human embryonic stem cells
The high proliferation rate of embryonic stem cells (ESCs) is thought to arise partly from very low expression of p21. However, how p21 is suppressed in ESCs has been unclear. We found that p53 binds to the p21 p...
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Article
Analysis of Hot Region Organization in Hub Proteins
Protein interaction maps constructed from binary interactions reveal that some proteins are highly connected to others (acting as hub proteins), whereas some others have a few interactions (at the edges of the...
