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Article
Open AccessMechanistic patterns and clinical implications of oncogenic tyrosine kinase fusions in human cancers
Tyrosine kinase (TK) fusions are frequently found in cancers, either as initiating events or as a mechanism of resistance to targeted therapy. Partner genes and exons in most TK fusions are followed typical re...
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Article
Open AccessWNT signalling control by KDM5C during development affects cognition
Although KDM5C is one of the most frequently mutated genes in X-linked intellectual disability1, the exact mechanisms that lead to cognitive impairment remain unknown. Here we use human patient-derived induced pl...
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Article
Open AccessExperimental approaches for manipulating choroid plexus epithelial cells
Choroid plexus (ChP) epithelial cells are crucial for the function of the blood-cerebrospinal fluid barrier (BCSFB) in the develo** and mature brain. The ChP is considered the primary source and regulator of...
