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  1. No Access

    Article

    A system for detecting high impact-low frequency mutations in primary tumors and metastases

    Tumor complexity and intratumor heterogeneity contribute to subclonal diversity. Despite advances in next-generation sequencing (NGS) and bioinformatics, detecting rare mutations in primary tumors and metastas...

    M Anjanappa, Y Hao, E R Simpson, P Bhat-Nakshatri, J B Nelson, S A Tersey… in Oncogene (2018)

  2. Article

    Open Access

    Accurate prediction of X-ray pulse properties from a free-electron laser using machine learning

    Free-electron lasers providing ultra-short high-brightness pulses of X-ray radiation have great potential for a wide impact on science, and are a critical element for unravelling the structural dynamics of mat...

    A. Sanchez-Gonzalez, P. Micaelli, C. Olivier, T. R. Barillot… in Nature Communications (2017)

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  3. No Access

    Article

    Regulation of LKB1 expression by sex hormones in adipocytes

    In the adipose tissue, activation of AMP-activated protein kinase (AMPK) by phosphorylation favours local fatty acid oxidation and inhibition of lipogenesis. We have previously shown that the potent androgen d...

    K J McInnes, K A Brown, N I Hunger, E R Simpson in International Journal of Obesity (2012)

  4. No Access

    Chapter

    Estrogen Signaling in the Regulation of Female Reproductive Functions

    Estrogens influence fertility and infertility in animals. This chapter reviews the use of estrogen as a contraceptive through the regulation of its production and action. It is concluded that the use of specif...

    J. K. Findlay, S. H. Liew, E. R. Simpson, K. S. Korach in Fertility Control (2010)

  5. No Access

    Article

    Evidence for the existence of an estrogen-responsive sexually dimorphic group of cells in the medial preoptic area of the 129SvEv mouse strain

    The current study describes the presence of sexually dimorphic cell groups within the MPO of the 129SvEv, but not the C57BL/6J strain of mice. We detected galanin-positive clusters of cells located in the MPO ...

    R A Hill, E R Simpson, W C Boon in International Journal of Impotence Research (2008)

  6. No Access

    Chapter and Conference Paper

    Of Mice and Men: The Many Guises of Estrogens

    Models of estrogen insufficiency have revealed new and unexpected roles for estrogens in males as well as females. These models include natural mutations in the aromatase gene in humans, as well as mouse knock...

    E. R. Simpson, M. E. Jones in Tissue-Specific Estrogen Action (2007)

  7. No Access

    Chapter and Conference Paper

    Role of Estrogens in the Male Reproductive Tract

    Most of the studies associated with defining the effects of estrogen have relied upon the use of models in which exogenous estrogens [17β-estradiol or diethylstilbestrol (DES)] are administered to rodents (Raijfe...

    E. R. Simpson, S. McPherson, M. Jones… in New Molecular Mechanisms of Estrogen Actio… (2004)

  8. No Access

    Chapter

    Tissue-Specific Regulation of Aromatase Cytochrome P450 (CYP19) Expression

    The conversion of androgens to estrogens is catalyzed by an enzyme complex known as aromatase, whose activity results in aromatization of the A ring of androgens, to form the phenolic A ring characteristic of ...

    E. R. Simpson, M. S. Mahendroo, G. D. Means, M. W. Kilgore, C. J. Corbin… in Cytochrome P450 (1993)

  9. No Access

    Chapter and Conference Paper

    Expression of P-450 Enzyme Activities in Heterologous Cells by Transfection

    The product of the A gene of simian virus 40 (SV40), T antigen, is synthesized and accumulates in the nucleus of infected cells. This regulartory protein acts to initiate viral DNA replication as well as regul...

    M. R. Waterman, J. I. Mason, M. X. Zuber… in Biological Monitoring of Exposure and the … (1989)