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Article
Open AccessValidated assays for the quantification of C9orf72 human pathology
A repeat expansion mutation in the C9orf72 gene is the leading known genetic cause of FTD and ALS. The C9orf72-ALS/FTD field has been plagued by a lack of reliable tools to monitor this genomic locus and its RNA ...
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Article
Over half of seniors who start oral bisphosphonate therapy are exposed for 3 or more years: novel rolling window approach and patterns of use
Most adherence studies only consider treatment following a first prescription. Using an extended follow-up, we found that 60% of seniors starting oral bisphosphonate therapy were exposed for ≥ 3 years (48% for...
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Article
Leptin regulation of the p53-HIF1α/PKM2-aromatase axis in breast adipose stromal cells: a novel mechanism for the obesity–breast cancer link
Obesity (body mass index (BMI)⩾30 kg m−2) is associated with an increased risk of estrogen-dependent breast cancer after menopause. Levels of aromatase, the rate-limiting enzyme in estrogen biosynthesis, are elev...
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Article
The High-Strain Rate Loading of Structural Biological Materials
The human body can be subjected to violent acceleration as a result of explosion caused by military ordinance or accident. Blast waves cause injury and blunt trauma can be produced by violent impact of objects...
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Article
Open AccessMitochondrial DNA copy number is regulated by DNA methylation and demethylation of POLGA in stem and cancer cells and their differentiated progeny
Mitochondrial DNA (mtDNA) copy number is strictly regulated during differentiation so that cells with a high requirement for ATP generated through oxidative phosphorylation have high mtDNA copy number, whereas...
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Article
Regulation of LKB1 expression by sex hormones in adipocytes
In the adipose tissue, activation of AMP-activated protein kinase (AMPK) by phosphorylation favours local fatty acid oxidation and inhibition of lipogenesis. We have previously shown that the potent androgen d...
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Article
Micronutrient recommendation stakeholders' beliefs on dietary guidelines: a qualitative study across six European countries/regions
A range of stakeholders have been involved in the development and implementation of dietary guidelines (DG) across Europe. Seventy-seven semi-structured qualitative interviews explored stakeholders' beliefs of...
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Chapter and Conference Paper
Performance of public private partnerships: An evolutionary perspective
PPPs are held to be a powerful way of mobilising private finance and resources to deliver public infrastructure. Theoretically, research into procurement has begun to acknowledge difficulties with the classifi...
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Article
Open AccessHER2 expression as a potential marker for response to therapy targeted to the EGFR
Since human epidermal growth factor receptor 2 (HER2) is known to participate with the epidermal growth factor receptor (EGFR) in mitogenic signalling, we hypothesised that HER2 overexpression might indicate r...
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Article
Binucleated and multinucleated forms of plasma cells in synovia from patients with rheumatoid arthritis
A morphological examination of synovial tissue from 25 patients with rheumatoid arthritis revealed that binucleated or multinucleated plasma cells were present in all samples and absent in synovia obtained fr...
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Article
Ventilatory parameters in children during propofol anaesthesia: a comparison with halothane
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Article
Pattern of ventilation during halothane anaesthesia in infants less than two months of age
To examine the breathing pattern of infants aged less than two months in order to understand better the effect of halothane on ventilation in infants.
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Article
Single Crystal Wurtzitic Aluminum Nitride Growth on Silicon Using Supersonic Gas Jets
Highly oriented aluminum nitride (0001) films have been grown on Si(001) and Si (111) substrates at temperatures between 550° C and 775° C with dual supersonic molecular beam sources. Triethylaluminum (TEA;[(C2H5
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Article
Ventilatory depression by halothane in infants and children
The purpose of this study was to extend previous observations of a greater decrease in tidal volume in infants than in children during halothane anaesthesia. We analyzed the inspiratory flow waveform recorded ...
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Article
A type VII myosin encoded by the mouse deafness gene shaker-1
GENETIC deafness is common, affecting about 1 in 2,000 births1. Many of these show primary abnormalities of the sensory neuro-epithelia of the inner ear, as do several hearing-impaired mouse mutants, suggesting t...
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Article
DNA in wheat seeds from European archaeological sites
We have used hybridization analysis to detect ancient DNA in wheat seeds collected from three archaeological sites in Europe and the Middle East. One of these samples, carbonizedT. spelta dated to the first mille...
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Article
Sequencing of the olfactory marker protein gene in normal and shaker-1 mutant mice
The mouse olfactory marker protein gene (Omp) maps close to the deafness mutation shaker-1 (sh-1) and has been considered a candidate gene for both sh-1 and its potential human homolog, the deaf-blind syndrome Us...
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Article
Abnormal binding properties of blood monocytes in rheumatoid arthritis
Blood monocytes from patients with RA exhibited a greater binding to monolayers of umbilical cord vein endothelium than monocytes from control subjects (mean 42% increase;p<0.01). When control monocytes were adde...
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Article
Immuno-electron microscopic analysis of the distribution of ICAM-1 in human inflammatory tissue
An immuno-electron microscopic analysis was undertaken to determine ICAM-1 expression on vascular endothelium in human tonsils and in synovia from patients with rheumatoid arthritis. ICAM-1 was preferentially ...
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Article
Minute ventilation during mask halothane anaesthesia in infants and children
The pattern of respiration in infants during anaesthesia is not well documented. In this study, minute ventilation (MV) during elective mask halothane anaesthesia (HA) was measured during spontaneous ventilati...
