Enzyme
Teil A
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Article
Metabolic gardening
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Chapter
Opening Lecture
Thank you very much, Dr. Kim and Professor Yagi and Dr. Ozawa and to other colleagues. There are, of course, many reasons why I am happy to say a few words at the opening of this symposium. First, and foremost...
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Chapter
Which Electron-Transferring Reactions in the Respiratory Chain Contribute to the Energy Conservation?
As starting point for this essay, it is assumed that the energy conserving act coupled with electron transfer in the mitochondrial respiratory chain is the transfer of negative charges from a specific site nea...
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Chapter
Diffusional Integration of Mitochondrial Function: Lateral Diffusion of Proteins in Energy Transduction
“The efficiency of the [succinic dehydrogenase-cytochrome] system depends ....... not only on the integrity of its components but also on that of the colloidal structure which supports them and assures their m...
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Chapter
Introductory Remarks
Having received no instructions, I am free to choose my own theme for these introductory remarks. I could have followed the other distinguished chairmen by talking about my own recent work. It is true that sin...
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Chapter
Cytochrome Systems: From Discovery to Present Developments
On March 21, at Magdalene College, Cambridge, where David Keilin was a Fellow, former students, colleagues and friends remembered his birth precisely 100 years earlier. It is appropriate, then, that in this In...
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Article
Albert L. Lehninger (1917 – 1986)
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Article
The mechanism of action of mitochondrial ATPase (ATP synthase)
The F1 part of the ATP synthase contains 6 nucleotide binding sites, four of which can be occupied and covalently labeled with 8-azido-adenine nucleotides. The other two sites contain tightly bound nucleotides th...
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Article
Identification of the BAL-labile factor
One of us has previously reported1 that treatment of the Keilin and Hartree heart–muscle preparation2 with 2,3-dimercaptopropanol (BAL), in the presence of air, leads to the complete inactivation of the succinate...
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Article
High-energy Forms of Cytochrome b
SUB-MITOCHONDRIAL particles prepared from horse or ox heart contain two species of cytochrome b in equal amounts, one (bi) affected by antimycin and the other (b) not affected1–3. In addition to its well known in...
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Chapter
Muscle Glyceraldehydephosphate Dehydrogenase: NAD+ Binding and its Implications for the Mechanism of Action of the Enzyme
The binding of NAD+ to rabbit-muscle glyceraldehydephosphate dehydrogenase (D-glyceraldehyde 3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12) has been studied extensively by several groups (1, 2, 3...
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Chapter and Conference Paper
Applications of Oligomycin and Related Inhibitors in Bioenergetics
Oligomycin is a fungicide made by Streptomyces diastatochromo- genes and related strains [1].
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Chapter and Conference Paper
Inhibitors Around the Antimycin-Sensitive Site in the Respiratory Chain
The region of the respiratory chain between cytochromes b and c1 is affected by several compounds in such a way as to lead to inhibition of electron transport. The site of action of these inhibitors is usually ca...
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Chapter
An Evaluation of the Mitchell Hypothesis of Chemiosmotic Coupling in Oxidative and Photosynthetic Phosphorylation
The Mitchell hypothesis of chemiosmotic coupling in oxidative phosphorylation is examined in the light of experimental data on oxidative phosphorylation at present available. The following objections are broug...
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Article
Labelling Rates and Detection of Intermediates in Mitochondrial Phosphorylations and other Sequential Reactions
BASED on his observation that mitochondrial protein-bound phosphohistidine becomes maximally labelled with added radioactive inorganic phosphate before maximum labelling of the mitochondrial ATP is reached, Pr...
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Article
Oxidases and Related Oxidation-Reduction Systems
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Book
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Article
Effect of Heavy Water on Respiratory-chain Enzymes
DURING radiobiological work on bacteria it was found by one of us (H. L.) that the effect of ionizing radiation (X-rays) is greatly potentiated if the bacteria are irradiated in a medium in which water is repl...
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Article
Need for Inorganic Phosphate in Oxidations stimulated by Dinitrophenol
Recently we have reported, in disagreement with the widely accepted view, that the maximal rate of oxygen uptake by respiring rat-liver or rat-heart mitochondria with glutamate as substrate is not obtained wit...
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Chapter
Der Chemismus der biologischen Oxydationen und Oxydoreduktionen
Unsere Vorstellungen über die Atmungskette, die den Haupt weg des Transportes von Elektronen oder Wasserstoff von den Stoffwechselsubstanzen zum Sauerstoff darstellt, sind als ein Ergebnis der Forschungen der ...
