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    Article

    The effect of cervical X-irradiation on activity index of thyrocytes and plasma TSH: A pre-clinical model for radiation-induced thyroid damage

    Because radiotherapy in the head and neck region is necessary in the treatment of childhood cancer, possibilities to prevent damage to the thyroid gland must be explored. We developed a model in which radiatio...

    H. M. van Santen MD, J. E. Van Dijk in Journal of Endocrinological Investigation (2005)

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    Article

    EcoRI RFLP in the human thyroid peroxidase (TPO) gene on chromosome 2

    The authors describe the source and characteristics of a new probe (pTP02/0.7EP).

    H. Bikker, P. A. Bolhuis, G. Vassart, F. Libert, G. Massaro in Human Genetics (1989)

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    Article

    DNA restriction fragment length polymorphisms in differential diagnosis of genetic disease: application in neuromuscular diseases

    Three families, in which several male individuals suffer from a hereditary neuromuscular disease, were examined by analysis of naturally occurring restriction fragment length polymorphisms (RFLPs) and by scree...

    J. C. Defesche, M. de Visser, E. Bakker, G. Bouwsma, J. J. M. de Vijlder in Human Genetics (1989)

  4. Article

    169 THE ETIOLOGY OF CONGENITAL HYPOTHYROIDISM (CHT) IN THE NETHERLANDS

    The Dutch national thyroid screening (measuring T4 and in the 20% samples with lowest T4 also TSH) was started in 1981. The abnormal screening results were evaluated 4 till 6 years later. Of the 176,311 screen...

    T Vulsma, M H Gons, G J Vaandrager, J J M de Vijlder in Pediatric Research (1988)

  5. Article

    RESTRICTION FRAGMENT LENGTH POLYMORPHISM (RFLP) STUDIES IN THYROGLOBULIN SYNTHESIS DEFECTS

    Data obtained from the screening on congenital hypothyroidism show that hereditary thyroid disorders in the Netherlands occur with an incidence of about 1:20,000. The etiologic classes we found in this populat...

    M H Cons, F Baas, H Bikker, T Vulsma, J J M de Vijlder in Pediatric Research (1988)

  6. Article

    Serum Thyroglobulin Levels in Preterm Infants with and without the Respiratory Distress Syndrome. I. Cord Blood Study

    Abstract: Cord serum levels of thyroglobulin (Tg) and thyroid stimulating hormone (TSH) in 147 term and preterm infants were related to gestation age, birth weight, respiratory distress syndrome (RDS), and sev...

    J H K Ok, W H H Tegelaers, J J M De Vijlder in Pediatric Research (1986)

  7. Article

    Serum Thyroglobulin Levels in Preterm Infants with and without Respiratory Distress Syndrome. II. A Longitudinal Study during the First 3 Weeks of Life

    Abstract: Serum thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) levels were measured in 182 preterm and term infants. Samples were taken from cord blood, and at 1, 3, 7, 14, and 21 days after birth. T...

    J H Kok, W H H Tegelaers, J J M De Vijlder in Pediatric Research (1986)

  8. Article

    ABNORMAL SKELETAL DEVELOPMENT IN GOATS WITH CONGENITAL HYPOTHYROIDISM

    In some infants with congenital hypothyroidism (CH) X-ray photographs of the long bones reveal increased mineral content and absence of the medullary cavity, resembling osteopetrosis. We studied this feature i...

    S A Goedegebuure, J E Van Dijk, J J M De Vijlder, R Steendijk in Pediatric Research (1985)

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    Article

    The human thyroglobulin gene: A polymorphic marker localized distal to C-MYC on chromosome 8 band q24

    The human thyroglobulin (Tg) gene is localized to chromosome 8 and regionally to band q24 as shown independently by both in situ hybridization techniques and Southern blot analysis of human-rodent somatic cell...

    F. Baas, H. Bikker, A. Geurts van Kessel, R. Melsert, P. L. Pearson in Human Genetics (1985)

  10. Article

    Excretion of iodohistidines, an important laboratory aid for the diagnosis of a special type of thyroidal disorder

    Iodohistidines were found in urines of patients with congenital goiter with abnormal iodoproteins (see also Savoie et al'). They were not detectable in urine of patients with other types of congenital goiter, ...

    M H Gons, J J M de Vijlder, T Can-Bos, W H H Tegelaers, R Steendijk in Pediatric Research (1978)

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    Chapter

    Muscle Glyceraldehydephosphate Dehydrogenase: NAD+ Binding and its Implications for the Mechanism of Action of the Enzyme

    The binding of NAD+ to rabbit-muscle glyceraldehydephosphate dehydrogenase (D-glyceraldehyde 3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12) has been studied extensively by several groups (1, 2, 3...

    J. J. M. De Vijlder, W. Boers, A. G. Hilvers in Pyridine Nucleotide-Dependent Dehydrogenas… (1970)