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  1. No Access

    Article

    Overlooked Issues on Pharmacokinetics Data Interpretation of Protein Drugs—a Case Example of Erythropoietin

    Guohua An, Robert L. Schmidt, Donald M. Mock, Peter Veng-Pedersen… in The AAPS Journal (2018)

  2. No Access

    Article

    A Novel Physiology-Based Mathematical Model to Estimate Red Blood Cell Lifespan in Different Human Age Groups

    Direct measurement of red blood cell (RBC) survival in humans has improved from the original accurate but limited differential agglutination technique to the current reliable, safe, and accurate biotin method....

    Guohua An, John A. Widness, Donald M. Mock, Peter Veng-Pedersen in The AAPS Journal (2016)

  3. No Access

    Article

    Models for the red blood cell lifespan

    The lifespan of red blood cells (RBCs) plays an important role in the study and interpretation of various clinical conditions. Yet, confusion about the meanings of fundamental terms related to cell survival an...

    Rajiv P. Shrestha, Joseph Horowitz… in Journal of Pharmacokinetics and Pharmacody… (2016)

  4. Article

    A Mass Balance-Based Semiparametric Approach to Evaluate Neonatal Erythropoiesis

    Postnatal hemoglobin (Hb) production in anemic preterm infants is determined by several factors including the endogenous erythropoietin levels, allogeneic RBC transfusions administered to treat anemia, and dev...

    Denison J. Kuruvilla, John A. Widness, Demet Nalbant, Robert L. Schmidt… in The AAPS Journal (2016)

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  5. Article

    A Method to Evaluate Fetal Erythropoiesis from Postnatal Survival of Fetal RBCs

    Fetal RBCs are produced during a period of very rapid growth and stimulated erythropoiesis under hypoxic intrauterine conditions. Fetal RBC life span varies with gestational age (GA) and is shorter than that i...

    Denison J. Kuruvilla, John A. Widness, Demet Nalbant, Robert L. Schmidt… in The AAPS Journal (2015)

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  6. No Access

    Article

    Measurement of 3-hydroxyisovaleric acid in urine from marginally biotin-deficient humans by UPLC-MS/MS

    Measurement of 3-hydroxyisovaleric acid (3HIA) in human urine has been shown to be a useful indicator of biotin status for a variety of clinical situations, including pregnancy. The work described herein prese...

    Thomas D. Horvath, Nell I. Matthews… in Analytical and Bioanalytical Chemistry (2011)

  7. No Access

    Protocol

    Biotin–Protein Bond: Instability and Structural Modification to Provide Stability for In Vivo Applications

    Biotinylation of proteins is a powerful tool for investigating biological phenomenon, both in vitro and in vivo. Biotinylating reagents that form covalent bonds with several types of amino acid residues are co...

    Donald M. Mock, Anna Bogusiewicz in Avidin-Biotin Interactions (2008)

  8. No Access

    Article

    Biotin transport and metabolism in the central nervous system

    The mechanisms by which biotin enters and leaves brain, choroid plexus and cerebrospinal fluid (CSF) were investigated by injecting [3H]biotin either intravenously or intraventricularly into adult rabbits. [3H]bi...

    Reynold Spector, DOnald M. Mock in Neurochemical Research (1988)