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Article
Open AccessPositron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo
Tissue environment is critical in determining tumour metabolic vulnerability. However, in vivo drug testing is slow and waiting for tumour growth delay may not be the most appropriate endpoint for metabolic tr...
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Article
Open AccessRadiosynthesis and Analysis of (S)-4-(3-[18F]Fluoropropyl)-L-Glutamic Acid
(S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is an L-glutamate derivative used as a PET biomarker to assess intracellular redox status in vivo through targeting of the cystine/glutamate antiporter prot...
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Article
Open AccessHigh molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET
Sodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing number of human studies being published using fluorine-18 radiolabelled t...
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Article
Open Access18F-C2Am: a targeted imaging agent for detecting tumor cell death in vivo using positron emission tomography
Trialing novel cancer therapies in the clinic would benefit from imaging agents that can detect early evidence of treatment response. The timing, extent and distribution of cell death in tumors following treat...
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Article
Open AccessCorrection to: The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models
Unfortunately, the original version of Figs. 4, 5 and 6b in the article [1] contained errors in the n numbers as indicated on the columns. Please note that column heights and error bars in the original figures an...
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Article
Open AccessImaging biomarker roadmap for cancer studies
Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the d...
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Article
Open AccessThe relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models
Recent studies have shown that 3′-deoxy-3′-[18F] fluorothymidine ([18F]FLT)) uptake depends on endogenous tumour thymidine concentration. The purpose of this study was to investigate tumour thymidine concentratio...
