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Article
Open AccessPositron emission tomography imaging of the sodium iodide symporter senses real-time energy stress in vivo
Tissue environment is critical in determining tumour metabolic vulnerability. However, in vivo drug testing is slow and waiting for tumour growth delay may not be the most appropriate endpoint for metabolic tr...
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Article
Open AccessHigh molar activity [18F]tetrafluoroborate synthesis for sodium iodide symporter imaging by PET
Sodium iodide symporter (NIS) imaging by positron emission tomography (PET) is gaining traction in nuclear medicine, with an increasing number of human studies being published using fluorine-18 radiolabelled t...
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Article
Open AccessIncreased apoptotic sensitivity of glioblastoma enables therapeutic targeting by BH3-mimetics
Glioblastoma (GBM) is the most prevalent malignant primary brain tumour in adults. GBM typically has a poor prognosis, mainly due to a lack of effective treatment options leading to tumour persistence or recur...
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Article
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
Oncogenic KRAS mutations and inactivation of the APC tumor suppressor co-occur in colorectal cancer (CRC). Despite efforts to target mutant KRAS directly, most therapeutic approaches focus on downstream pathways,...
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Article
Open Access18F-Fluciclovine PET metabolic imaging reveals prostate cancer tumour heterogeneity associated with disease resistance to androgen deprivation therapy
Prostate cancer is highly prevalent worldwide. Androgen deprivation therapy (ADT) remains the treatment of choice for incurable prostate cancer, but majority of patients develop disease recurrence following AD...
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Article
Mannose impairs tumour growth and enhances chemotherapy
It is now well established that tumours undergo changes in cellular metabolism1. As this can reveal tumour cell vulnerabilities and because many tumours exhibit enhanced glucose uptake2, we have been interested i...
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Applications of Molecular Small-Animal Imaging in Inflammation and Infection
In the past decades, the field of molecular imaging of inflammation/infection has enormously expanded because of the huge clinical need for diagnostic, prognostic and therapeutic purposes.
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Article
Biological Therapies for Rheumatoid Arthritis: Progress to Date
Biologic drugs for the management of rheumatoid arthritis (RA) have revolutionized the therapeutic armamentarium with the development of several novel monoclonal antibodies, which include murine, chimeric, hum...
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Article
Open AccessSynthesis and Evaluation of 99mTc-Labelled Monoclonal Antibody 1D09C3 for Molecular Imaging of Major Histocompatibility Complex Class II Protein Expression
It is known that major histocompatibility complex class II protein HLA-DR is highly expressed in B-cell lymphomas and in a variety of autoimmune and inflammatory diseases. Therefore, a radiolabelled fully huma...
