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Lightning-induced features on granitic gneiss and its implication for rare lightning scars from the geological record
Cloud-to-ground lightning can cause high-temperature and high-pressure deformation features in rock at the strike point, forming fulgurite. Although cloud-to-ground lightning is a frequent phenomenon, rock ful...
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Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis
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Open AccessNeutrophils incite and macrophages avert electrical storm after myocardial infarction
Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia and massive myocardial leukoc...
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Open AccessSimultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury
Chronic kidney diseases and acute kidney injury are mechanistically distinct kidney diseases. While chronic kidney diseases are associated with podocyte injury, acute kidney injury affects renal tubular epithe...
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Cerebrospinal fluid can exit into the skull bone marrow and instruct cranial hematopoiesis in mice with bacterial meningitis
Interactions between the immune and central nervous systems strongly influence brain health. Although the blood–brain barrier restricts this crosstalk, we now know that meningeal gateways through brain border ...
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B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis
Autonomic nerves control organ function through the sympathetic and parasympathetic branches, which have opposite effects. In the bone marrow, sympathetic (adrenergic) nerves promote hematopoiesis; however, ho...
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Open AccessA non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine
Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about how metabolic reprogramming contributes to early stages of transformation. Here, we show that the histone deacetylas...
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Open AccessLightning-induced high temperature and pressure microstructures in surface and subsurface fulgurites
Cloud-to-ground lightning causes both high-temperature and high-pressure metamorphism of rocks, forming rock fulgurite. We demonstrate that a range of microstructural features indicative of high temperatures a...
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Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia
Neurodegeneration occurring in multiple sclerosis (MS) contributes to the progression of disability. It is therefore important to identify and neutralize the mechanisms that promote neurodegeneration in MS. He...
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Open AccessExercise rapidly alters proteomes in mice following spinal cord demyelination
Exercise affords broad benefits for people with multiple sclerosis (PwMS) including less fatigue, depression, and improved cognition. In animal models of multiple sclerosis (MS), exercise has been shown to imp...
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Combination of Hydroxychloroquine and Indapamide Attenuates Neurodegeneration in Models Relevant to Multiple Sclerosis
As the underlying pathophysiology of progressive forms of multiple sclerosis (MS) remains unclear, current treatment strategies are inadequate. Progressive MS is associated with increased oxidative stress and ...
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Open AccessPatient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology
Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique organoids an...
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Open AccessDianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells
1,2:5,6-Dianhydrogalactitol (DAG) is a bi-functional DNA-targeting agent currently in phase II clinical trial for treatment of temozolomide-resistant glioblastoma (GBM). In the present study, we investigated t...
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Open AccessImaging active faulting in the western Taiwan Strait
Large, destructive historical earthquakes off the coast of China’s Fujian Province point to important tectonic activity in the western Taiwan Strait that, until recently, has received little attention. We pres...
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Open AccessDianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination
1,2:5,6-Dianhydrogalactitol (DAG) is a bifunctional DNA-targeting agent causing N7-guanine alkylation and inter-strand DNA crosslinks currently in clinical trial for treatment of glioblastoma. While preclinical s...
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Open AccessTyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging
Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrie...
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Open AccessMap** the H+ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation
V-ATPases (H+ ATPases) are multisubunit, ATP-dependent proton pumps that regulate pH homeostasis in virtually all eukaryotes. They are involved in key cell biological processes including vesicle trafficking, endo...
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V-ATPase interacts with ARNO and Arf6 in early endosomes and regulates the protein degradative pathway
The recruitment of the small GTPase Arf6 and ARNO from cytosol to endosomal membranes is driven by V-ATPase-dependent intra-endosomal acidification. The molecular mechanism that mediates this pH-sensitive recr...
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TRPC6 is a glomerular slit diaphragm-associated channel required for normal renal function
Progressive kidney failure is a genetically and clinically heterogeneous group of disorders. Podocyte foot processes and the interposed glomerular slit diaphragm are essential components of the permeability ba...
