-
Article
Open AccessThe RNA binding protein IGF2BP2/IMP2 alters the cargo of cancer cell-derived extracellular vesicles supporting tumor-associated macrophages
Tumor cells release extracellular vesicles (EVs) that contribute to the polarization of macrophages towards tumor-associated macrophages (TAMs). High expression levels of the RNA binding protein IGF2BP2/IMP2 a...
-
Article
Open AccessSpray-dried lactose-leucine microparticles for pulmonary delivery of antimycobacterial nanopharmaceuticals
Pulmonary delivery of nanocarriers for novel antimycobacterial compounds is challenging because the aerodynamic properties of nanomaterials are sub-optimal for such purposes. Here, we report the development of...
-
Article
Combination of Hydroxychloroquine and Indapamide Attenuates Neurodegeneration in Models Relevant to Multiple Sclerosis
As the underlying pathophysiology of progressive forms of multiple sclerosis (MS) remains unclear, current treatment strategies are inadequate. Progressive MS is associated with increased oxidative stress and ...
-
Chapter
Landwirtschaftspolitik unter Grün-Schwarz: Kompromissfindung anhand des Leitbilds der bäuerlichen Landwirtschaft
Die Landwirtschaftspolitik ist für die CDU von besonderer Bedeutung. In der Vergangenheit hat sie sich als Fürsprecherin der Landwirtinnen und -wirte gesehen. Die Grünen hingegen haben sich traditionell für di...
-
Article
Open AccessThe synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB
We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of Cl...
-
Article
Open AccessKinetics of mRNA delivery and protein translation in dendritic cells using lipid-coated PLGA nanoparticles
Messenger RNA (mRNA) has gained remarkable attention as an alternative to DNA-based therapies in biomedical research. A variety of biodegradable nanoparticles (NPs) has been developed including lipid-based and...
-
Article
Open AccessSystematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic
The treatment of progressive multiple sclerosis (MS) is unsatisfactory. One reason is that the drivers of disease, which include iron-mediated neurotoxicity, lymphocyte activity, and oxidative stress, are not ...
-
Article
Epithelial–mesenchymal transition of the retinal pigment epithelium causes choriocapillaris atrophy
Epithelial-to-mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is commonly observed at sites of choroidal neovascularization in patients suffering from age-related macular degeneration. To ...
-
Article
Open AccessAn inhibitor of chondroitin sulfate proteoglycan synthesis promotes central nervous system remyelination
Remyelination is the generation of new myelin sheaths after injury facilitated by processes of differentiating oligodendrocyte precursor cells (OPCs). Although this repair phenomenon occurs in lesions of multi...
-
Article
Open AccessLipid droplets as a novel cargo of tunnelling nanotubes in endothelial cells
Intercellular communication is a fundamental process in the development and functioning of multicellular organisms. Recently, an essentially new type of intercellular communication, based on thin membrane chan...
-
Article
Editorial
-
Article
Novel Galvanic Nanostructures of Ag and Pd for Efficient Laser Desorption/Ionization of Low Molecular Weight Compounds
A simple approach for synthesis of palladium and silver nanostructures with readily adjustable morphologies was developed using galvanic electrochemical deposition, for application to surface-assisted laser de...
-
Article
On the origin and evolution of apomixis in Boechera
The genetic mechanisms causing seed development by gametophytic apomixis in plants are predominantly unknown. As apomixis is consistently associated with hybridity and polyploidy, these confounding factors may...
-
Article
Use of a silver ion selective electrode to assess mechanisms responsible for biological effects of silver nanoparticles
For a detailed analysis of the biological effects of silver nanoparticles, discrimination between effects related to the nano-scale size of the particles and effects of released silver ions is required. Silver...
-
Article
Open AccessHigh gene flow in epiphytic ferns despite habitat loss and fragmentation
Tropical montane forests suffer from increasing fragmentation and replacement by other types of land-use such as coffee plantations. These processes are known to affect gene flow and genetic structure of plant...
-
Article
Open AccessDifferential cell reaction upon Toll-like receptor 4 and 9 activation in human alveolar and lung interstitial macrophages
Investigations on pulmonary macrophages (MΦ) mostly focus on alveolar MΦ (AM) as a well-defined cell population. Characteristics of MΦ in the interstitium, referred to as lung interstitial MΦ (IM), are rather ...
-
Article
Spatial arrangement and genetic structure in Gentianella aspera in a regional, local, and temporal context
Gentianella aspera is a biennial plant of various nutrient-poor grasslands that has become rare in the landscapes outside the Alps of eastern Austria. Using AFLP fingerprinting we investigated: (1) effects of spa...
-
Chapter
Studying Adaptive Radiation at the Molecular Level: A Case Study in the Macaronesian Crassulaceae-Sempervivoideae
Oceanic islands frequently harbour prominent examples of plant radiations. Here, we investigated the Macaronesian Crassulaceae-Sempervivoideae (MCS) including the genera Aichryson, Monanthes and Aeonium. This spe...
-
Article
Molecular evolution and phylogenetic utility of non-coding DNA: applications from species to deep level questions
-
Article
In situ growth of the novel SM1 euryarchaeon from a string-of-pearls-like microbial community in its cold biotope, its physical separation and insights into its structure and physiology
Recently, a unique archaeal/bacterial community that grows in a macroscopically visible string-of-pearls-like structure in cold (~10 °C), sulfurous marsh water was discovered. Here, a new technique is describe...
