14 Result(s)

Article

Author Correction: B lymphocyte-derived acetylcholine limits steady-state and emergency hematopoiesis

Maximilian J. Schloss, Maarten Hulsmans, David Rohde, I-Hsiu Lee… in Nature Immunology (2022)

Article

Neutrophils incite and macrophages avert electrical storm after myocardial infarction

Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia and massive myocardial leukoc...

Jana Grune, Andrew J. M. Lewis, Masahiro Yamazoe… in Nature Cardiovascular Research (2022)

Article

Simultaneous stabilization of actin cytoskeleton in multiple nephron-specific cells protects the kidney from diverse injury

Chronic kidney diseases and acute kidney injury are mechanistically distinct kidney diseases. While chronic kidney diseases are associated with podocyte injury, acute kidney injury affects renal tubular epithe...

Kamalika Mukherjee, Changkyu Gu, Agnieszka Collins, Marcel Mettlen… in Nature Communications (2022)

Article

A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine

Although reprogramming of cellular metabolism is a hallmark of cancer, little is known about how metabolic reprogramming contributes to early stages of transformation. Here, we show that the histone deacetylas...

Carlos Sebastian, Christina Ferrer, Maria Serra, Jee-Eun Choi… in Nature Communications (2022)

Article

Lightning-induced high temperature and pressure microstructures in surface and subsurface fulgurites

Cloud-to-ground lightning causes both high-temperature and high-pressure metamorphism of rocks, forming rock fulgurite. We demonstrate that a range of microstructural features indicative of high temperatures a...

Li-Wei Kuo, Steven A. F. Smith, Chien-Chih Chen, Ching-Shun Ku… in Scientific Reports (2021)

Article

Exercise rapidly alters proteomes in mice following spinal cord demyelination

Exercise affords broad benefits for people with multiple sclerosis (PwMS) including less fatigue, depression, and improved cognition. In animal models of multiple sclerosis (MS), exercise has been shown to imp...

Brian Mark Lozinski, Luiz Gustavo Nogueira de Almeida, Claudia Silva… in Scientific Reports (2021)

Article

Combination of Hydroxychloroquine and Indapamide Attenuates Neurodegeneration in Models Relevant to Multiple Sclerosis

As the underlying pathophysiology of progressive forms of multiple sclerosis (MS) remains unclear, current treatment strategies are inadequate. Progressive MS is associated with increased oxidative stress and ...

Dennis Brown, Dorsa Moezzi, Yifei Dong, Marcus Koch, V. Wee Yong in Neurotherapeutics (2021)

Article

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Patient-based cancer models are essential tools for studying tumor biology and for the assessment of drug responses in a translational context. We report the establishment a large cohort of unique organoids an...

Anna Golebiewska, Ann-Christin Hau, Anaïs Oudin, Daniel Stieber… in Acta Neuropathologica (2020)

Article

Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells

1,2:5,6-Dianhydrogalactitol (DAG) is a bi-functional DNA-targeting agent currently in phase II clinical trial for treatment of temozolomide-resistant glioblastoma (GBM). In the present study, we investigated t...

Beibei Zhai, Yue Li, Sudha Sravanti Kotapalli, Jeffrey Bacha… in Cell Death & Disease (2020)

Article

Imaging active faulting in the western Taiwan Strait

Large, destructive historical earthquakes off the coast of China’s Fujian Province point to important tectonic activity in the western Taiwan Strait that, until recently, has received little attention. We pres...

Yifeng Zhang, Hao Kuo-Chen, Joaquina Alvarez-Marron, Dennis Brown… in Scientific Reports (2020)

Article

Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination

1,2:5,6-Dianhydrogalactitol (DAG) is a bifunctional DNA-targeting agent causing N⁷-guanine alkylation and inter-strand DNA crosslinks currently in clinical trial for treatment of glioblastoma. While preclinical s...

Beibei Zhai, Anne Steinø, Jeffrey Bacha, Dennis Brown… in Cell Death & Disease (2018)

Article

Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging

Epithelial cells are generally considered to be static relative to their neighbours. Basal cells in pseudostratified epithelia display a single long cytoplasmic process that can cross the tight junction barrie...

Jeremy Roy, Bongki Kim, Eric Hill, Pablo Visconti, Dario Krapf… in Nature Communications (2016)

Article

Map** the H⁺ (V)-ATPase interactome: identification of proteins involved in trafficking, folding, assembly and phosphorylation

V-ATPases (H⁺ ATPases) are multisubunit, ATP-dependent proton pumps that regulate pH homeostasis in virtually all eukaryotes. They are involved in key cell biological processes including vesicle trafficking, endo...

Maria Merkulova, Teodor G. Păunescu, Anie Azroyan… in Scientific Reports (2015)

Article

Erratum: In colchicine-treated rats, cellular distribution of AQP-1 in convoluted and straight proximal tubule segments is differently affected

Sabolic Ivan, Baus Mirela, Medjugorac-Popovski Mila, Dennis Brown in Pflügers Archiv (2000)