5 Result(s)
within
David J Hunter
Health Promotion and Disease Prevention
Surgical Oncology
-
Article
Open AccessGenome-wide association study of susceptibility loci for breast cancer in Sardinian population
Despite progress in identifying genes associated with breast cancer, many more risk loci exist. Genome-wide association analyses in genetically-homogeneous populations, such as that of Sardinia (Italy), could ...
-
Article
Open AccessGenetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Gonadotropin releasing hormone (GNRH1) triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may influence...
-
Article
Open AccessGenetic variants in FGFR2 and FGFR4 genes and skin cancer risk in the Nurses' Health Study
The human fibroblast growth factor (FGF) and its receptor (FGFR) play an important role in tumorigenesis. Deregulation of the FGFR2 gene has been identified in a number of cancer sites. Overexpression of the FGFR...
-
Article
Open AccessTGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study
Transforming growth factor beta 1 (TGFB1) forms a signaling complex with transforming growth factor beta receptors 1 and 2 and has been described as both a tumor suppressor and tumor promoter. Single nucleotid...
-
Article
Open AccessGene × Gene interaction between MnSOD and GPX-1 and breast cancer risk: a nested case-control study
Germ-line mutations in genes such as BRCA1, BRCA2, and ATM can cause a substantial increase in risk of breast cancer. However, these mutations are rare in the general population, and account for little of the inc...
