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358 Result(s)
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Article
Effect of Dy3+on osteogenic and adipogenic differentiation of mouse primary bone marrow stromal cells and adipocytic trans-differentiation of mouse primary osteoblasts
A series of experimental methods including 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) test, alkaline phosphatase (ALP) activity measurement, mineralized function, Oil Red O stain and m...
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Article
The effects of gold nanoparticles on the proliferation, differentiation, and mineralization function of MC3T3-E1 cells in vitro
This study has investigated the effects of gold nanoparticles (Au NPs) on the proliferation, differentiation, and mineralization of a murine preosteoblast cell line MC3T3-E1 in vitro. The results show that Au NPs...
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Article
Coexistence of the topological state and a two-dimensional electron gas on the surface of Bi2Se3
The surface of a topological insulator plays host to an odd number of linearly-dispersing Dirac fermions, protected against back-scattering by time-reversal symmetry. Such characteristics make these materials ...
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Open AccessMolecular dissection of plant height QTLs using recombinant inbred lines from hybrids between common wheat (Triticum aestivum L.) and spelt wheat (Triticum spelta L.)
In wheat, plant height is an important agronomic trait, and a number of quantitative trait loci (QTLs) controlling plant height have been located. In this study, using the conditional and unconditional QTL map...
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Article
Open AccessElectrodeposition of Ni micro/nano-structures
A quasi two-dimension electrodeposition method was used to prepare materials with arborized, tree-shaped, and membrane patterned micro/nano-structures. The morphology of the membrane patterned micro/nano-struc...
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Article
Open AccessCharacter and fabrication of Al/Al2O3/Al tunnel junctions for qubit application
The superconductive Josephson junction is the key device for superconducting quantum computation. We have fabricated Al/Al2O3/Al tunnel junctions using a double angle evaporation method based on a suspended shado...
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Article
The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends
Nucleolytic degradation of 5′ strands at DNA double-strand breaks in yeast is shown to be facilitated by the nucleosome remodeller Fun30, particularly within chromatin bound by the checkpoint adaptor protein k...
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Open AccessProgress of regional oceanography study associated with western boundary current in the South China Sea
Recent progress of physical oceanography in the South China Sea (SCS) associated with the western boundary current (WBC) and eddies is reviewed in this paper. It includes Argo observations of the WBC, eddy det...
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Article
Open AccessIsolation and characterization of class I MHC genes in the giant panda (Ailuropoda melanoleuca)
Artificial breeding is an important project to protect, recover and reintroduce endangered species. Knowledge of the population’s genetic diversity at functional loci is important for the establishment of effe...
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Article
Open Accessp53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1
The p53 tumour suppressor has an important role in cancer cells. Here we show that p53 regulates expression of major histocompatibility complex I on the cell surface. We show that the tumour cell line HCT116, ...
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Article
Distribution and risk factors of hand, foot, and mouth disease in Changchun, northeastern China
Hand, foot, and mouth disease (HFMD) is a public health problem, and there have been increasing numbers of outbreaks in mainland China since 2008. Over 17,000 HFMD cases have been reported in Changchun between...
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Open AccessPorphyrin–phospholipid liposomes permeabilized by near-infrared light
The delivery of therapeutic compounds to target tissues is a central challenge in treating disease. Externally controlled drug release systems hold potential to selectively enhance localized delivery. Here we ...
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Article
Open AccessSurrounding Sensitive Electronic Properties of Bi2Te3 Nanoplates—Potential Sensing Applications of Topological Insulators
Significant efforts have been paid to exploring the fundamental properties of topological insulators (TIs) in recent years. However, the investigation of TIs as functional materials for practical device applic...
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Article
Open AccessGr-1+CD11b+ cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation
Studies have shown that bone marrow-derived cells play an important role in tumor recurrence after chemotherapy and radiotherapy. In this study, we examined the relationship between the accumulation of Gr-1+CD...
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Article
Structure of the human P2Y12 receptor in complex with an antithrombotic drug
The X-ray crystal structure of the human P2Y12 receptor, which regulates platelet activation and thrombus formation, is solved in complex with an antithrombotic drug, providing insights for the development of new...
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Article
Agonist-bound structure of the human P2Y12 receptor
An X-ray structure of human P2Y12 receptor, a clinical drug target for platelet aggregation inhibitors, is presented in complex with an agonist, providing insight into the δ-group of class A G-protein-coupled rec...
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Article
Open AccessTranscriptional control of ROS homeostasis by KUODA1 regulates cell expansion during leaf development
The final size of an organism, or of single organs within an organism, depends on an intricate coordination of cell proliferation and cell expansion. Although organism size is of fundamental importance, the mo...
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Article
Open AccessFrequent KIT Mutations in Human Gastrointestinal Stromal Tumors
Identifying gene mutations in individual tumors is critical to improve the efficacy of cancer therapy by matching targeted drugs to specific mutations. Gastrointestinal stromal tumors (GIST) are stromal or mes...
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Article
The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics
Maternal effect genes play critical roles in early embryogenesis of model organisms where they have been intensively investigated. However, their molecular function in mammals remains largely unknown. Recently...
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Article
SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain
Heart failure (HF) is associated with complicated molecular remodelling within cardiomyocytes; however, the mechanisms underlying this process remain unclear. Here we show that sorting nexin-13 (SNX13), a memb...