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  1. No Access

    Article

    Dna2 nuclease deficiency results in large and complex DNA insertions at chromosomal breaks

    Insertions of mobile elements1–4, mitochondrial DNA5 and fragments of nuclear chromosomes6 at DNA double-strand breaks (DSBs) threaten genome integrity and are common in cancer7–9. Insertions of chromosome fragme...

    Yang Yu, Nhung Pham, Bo **a, Alma Papusha, Guangyu Wang, Zhenxin Yan, Guang Peng… in Nature (2018)

  2. No Access

    Article

    The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends

    Nucleolytic degradation of 5′ strands at DNA double-strand breaks in yeast is shown to be facilitated by the nucleosome remodeller Fun30, particularly within chromatin bound by the checkpoint adaptor protein k...

    Xuefeng Chen, Dandan Cui, Alma Papusha, **aotian Zhang, Chia-Dwo Chu… in Nature (2012)

  3. No Access

    Article

    Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation

    Resection of DNA 5′ ends is the initial step for repair of double-strand breaks via homologous recombination. DNA resection is controlled in a cell-cycle dependent manner, with yeast Cdk1 known to control Sae2...

    Xuefeng Chen, Hengyao Niu, Woo-Hyun Chung, Zhu Zhu… in Nature Structural & Molecular Biology (2011)

  4. No Access

    Article

    Smc5–Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination

    DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that th...

    Giacomo De Piccoli, Felipe Cortes-Ledesma, Gregory Ira… in Nature Cell Biology (2006)