17 Result(s)
within
D. Tibboel
Pediatric Surgery
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Article
Insights Image for “Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats”
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Article
Repetitive noxious stimuli during early development affect acute and long-term mechanical sensitivity in rats
Prematurely born infants are frequently exposed to painful procedures in the neonatal intensive care unit, causing changes to the development of the nervous system lasting into adulthood. The current study aim...
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Article
Changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation
Thyroid hormone concentrations can be disturbed during critical illness. Our aim was to determine changes in thyroid hormone concentrations during neonatal extracorporeal membrane oxygenation (ECMO).
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Article
Children’s outcomes at 2-year follow-up after 4 years of structured multi-professional medical-ethical decision-making in a neonatal intensive care unit
We reviewed our decisions about continuation/withdrawal of life-sustaining treatments in a group of critically ill newborns who were discussed in structured medical ethical decision-making meetings, and provid...
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Article
144 Incidence, Risk Factors and Severity of Pulmonary Morbidity in Infants with Congenital Diaphragmatic Hernia Born in High-Volume Centres in Europe
Background and aims: Newborns with congenital diaphragmatic hernia (CDH) may develop chronic lung disease (CLD). Our aim was to determine the incidence, severity and risk factors of CLD in infants with CDH.
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Article
Open AccessCan we improve outcome of congenital diaphragmatic hernia?
This review gives an overview of the disease spectrum of congenital diaphragmatic hernia (CDH). Etiological factors, prenatal predictors of survival, new treatment strategies and long-term morbidity are descri...
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Article
Genetics and developmental biology of oesophageal atresia and tracheo-oesophageal fistula: lessons from mice relevant for paediatric surgeons
Oesophageal atresia and tracheo-oesophageal fistula are relatively frequently occurring foregut malformations of which the aetiology and pathogenesis are poorly understood. Recent results of molecular genetic ...
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Article
7 Ontogeny of Udp-Glucuronosyltransferase Activity During Repeated Administration of Propacetamol in Neonates
Background: Major changes in drug clearance are observed during infancy, at least partially based on ontogenic regulation of metabolic pathways but data on maturation of UDP-glucuronosyltransferase (UGT)-activity...
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Article
276 Neonates With Severe Respiratory Insufficiency Requiring ECMO Have Decreased Surfactant Synthesis
Background: Respiratory insufficiency in neonates with congenital diaphragmatic hernia (CDH), meconium aspiration syndrome (MAS) or other forms of persistent pulmonary hypertensin of the newborn (PPHN) is frequen...
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Article
6 Impact of Administration of Analgesics During Neonatal Stay on Pain Expression Following Neonatal Stay in Former Preterm Infants
Introduction: There are still few data on the impact of pharmacologic treatment of pain during neonatal stay in preterm infants on pain expression after neonatal stay. We therefore investigated pain expression in...
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Article
Tracheal Ligation and Corticosteroids in Congenital Diaphragmatic Hernia: For Better for Worse?
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Article
“Gut-feeling” or evidence-based approaches in the evaluation and treatment of human short-bowel syndrome
Short bowel syndrome is the malabsorptive state that often follows extensive resection of the small intestine. Long-term survival without parenteral nutrition depends on the process of intestinal adaptation, ...
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Article
End-results of experimental gastroschisis created by abdominal wall versus umbilical cord defect
An experimental study was conducted to determine the end-results of two different defects on the anterior abdominal wall: an abdominal wall defect (AWD) versus an umbilical cord defect (UCD) using chick embryo...
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Article
Congenital diaphragmatic hernia: new models, new ideas
An animal model for congenital diaphragmatic hernia following interference with the development of the primary lung bud by 2,4-dinitro-p-diphenylether (nitrofen) is described. It has been used for pathogenetic st...
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Chapter and Conference Paper
Diagnosis of Innervation-Related Motility Disorders of the Gut and Basic Aspects of Enteric Nervous System Development
Motility disorders of the gut in children have become a matter of increasing concern for the pediatric surgeon. Infantile hypertrophic pyloric stenosis is the most common disease requiring surgery in early inf...
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Article
Prospective evaluation of postoperative morbidity in patients with esophageal atresia
Patients treated for esophageal atresia during 1984 and 1985 were evaluated prospectively to ensure early detection and treatment of gastroesophageal reflux, in an attempt to reduce postoperative morbidity. A ...
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Article
Postoperative morbidity in patients with esophageal atresia
A retrospective study was carried out in 110 patients with esophageal atresia seen at the Sophia Children's Hospital, Rotterdam, from 1975 to 1984. Special attention was paid to post-operative morbidity in vie...
