66 Result(s)

Chapter and Conference Paper

Brain Anatomy in Schizophrenia: Discussion

I would like to begin my discussion by congratulating Drs. Bogerts, Gattaz, and Nasrallah for excellent reviews of recent developments in the study of anatomical deviations in the brains of patients with schiz...

D. R. Weinberger in Search for the Causes of Schizophrenia (1991)

Chapter and Conference Paper

Structural Brain Changes in Schizophrenia: The Issue of Subgroups

Developments in modern neuroimaging techniques have significantly advanced our ability to examine brain structures in living subjects. As a result, replicable neuropathological changes have been demonstrated i...

L. Marsh, D. R. Weinberger in Imaging of the Brain in Psychiatry and Related Fields (1993)

Article

Autoradiographic characterization of neurotensin receptors in the entorhinal cortex of schizophrenic patients and control subjects

Neurotensin, an endogenous peptide and putative neurotransmitter, exhibits a wide range of interactions with dopaminergic neurons and displays some actions akin to neuroleptics. Moreover, neurotensin receptors...

S. S. Wolf, T. M. Hyde, R. C. Saunders… in Journal of Neural Transmission / General S… (1995)

Article

Prodynorphin mRNA expression is increased in the patch vs matrix compartment of the caudate nucleus in suicide subjects

Experimental and clinical studies suggest an involvement of the opioid neuropeptide system in psychiatric disorders. Notably, opioid peptide immunoreactivity is altered in the cerebrospinal fluid of chronic sc...

Y L Hurd, M M Herman, T M Hyde, L B Bigelow, D R Weinberger… in Molecular Psychiatry (1997)

Article

Attenuated extracellular dopamine levels after stress and amphetamine in the nucleus accumbens of rats with neonatal ventral hippocampal damage

In vivo microdialysis was used to study the effects of restraint stress (30 min) and amphetamine (AMPH) (5 mg/kg, i.p.) in awake adult male rats with neonatal ventral hippocampal (VH) damage. Extracellular le...

S. M. Lillrank, B. K. Lipska, B. S. Kolachana… in Journal of Neural Transmission (1999)

Chapter

Schizophrenie: Die neurobiologische Entwicklungshypothese

Kraepelin faßte die Schizophrenie als eine frühzeitige Demenz auf, die in der 2. oder 3. Lebensdekade auftritt und sich im Verlauf der Erkrankung verschlechtert (Kraepelin 1899). Sowohl Bleuler (1911) als auch...

A. Heinz, D. R. Weinberger in Psychiatrie der Gegenwart 5 (2000)

Chapter

Schizophrenia: The Neurodevelopmental Hypothesis

Kraepelin conceptualized schizophrenia as a premature dementia, presenting in the second or third decade of life and deteriorating over the course of the illness (Kraepelin 1899). Both Bleuler (1911) and Kraep...

A. Heinz, D. R. Weinberger in Contemporary Psychiatry (2001)

Article

Developmental and stress-related changes of neurotrophic factor gene expression in an animal model of schizophrenia

The neonatal (PND 7) lesion of the ventral hippocampus (VH) with ibotenic acid represents a well-established experimental paradigm that recapitulates many schizophrenia-like phenomena. In order to investigate ...

R Molteni, B K Lipska, D R Weinberger, G Racagni, M A Riva in Molecular Psychiatry (2001)

Article

Serotonin transporter availability correlates with alcohol intake in non-human primates

A low level of alcohol intoxication upon initial exposure and impulsive aggressiveness predispose humans to alcoholism. In non-human primates, central serotonin transporter availability and turnover rate were ...

A Heinz, D W Jones, J G Gorey, A Bennet, S J Suomi, D R Weinberger… in Molecular Psychiatry (2003)

Article

Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia

Anatomical and molecular abnormalities of excitatory neurons in the dorsolateral prefrontal cortex (DLPFC) are found in schizophrenia. We hypothesized that brain-derived neurotrophic factor (BDNF), a protein c...

C S Weickert, T M Hyde, B K Lipska, M M Herman, D R Weinberger… in Molecular Psychiatry (2003)

Article

Presynaptic proteins in the prefrontal cortex of patients with schizophrenia and rats with abnormal prefrontal development

Dysfunction of the prefrontal cortex in schizophrenia may be associated with abnormalities in synaptic structure and/or function and reflected in altered concentrations of proteins in presynaptic terminals and...

N D Halim, C S Weickert, B W McClintock, T M Hyde, D R Weinberger… in Molecular Psychiatry (2003)

Article

Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia

Genetic linkage and association have implicated neuregulin-1 (NRG-1) as a schizophrenia susceptibility gene. We measured mRNA expression levels of the three major isoforms of NRG-1 (ie type I, type II, and typ...

R Hashimoto, R E Straub, C S Weickert, T M Hyde, J E Kleinman… in Molecular Psychiatry (2004)

Article

Schizophrenia genes within cortical neural circuits

P J Harrison, D R Weinberger in Molecular Psychiatry (2005)

Article

Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence

This review critically summarizes the neuropathology and genetics of schizophrenia, the relationship between them, and speculates on their functional convergence. The morphological correlates of schizophrenia ...

P J Harrison, D R Weinberger in Molecular Psychiatry (2005)

Article

GAD1 (2q31.1), which encodes glutamic acid decarboxylase (GAD₆₇), is associated with childhood-onset schizophrenia and cortical gray matter volume loss

Postmortem brain studies have shown deficits in the cortical γ-aminobutyric acid (GABA) system in schizophrenic individuals. Expression studies have shown a decrease in the major GABA-synthesizing enzyme (glutami...

A M Addington, M Gornick, J Duckworth, A Sporn, N Gogtay, A Bobb… in Molecular Psychiatry (2005)

Article

Reductions in neurotrophin receptor mRNAs in the prefrontal cortex of patients with schizophrenia

Patients with schizophrenia have reduced neurotrophin levels in their dorsolateral prefrontal cortex (DLPFC) compared to normal unaffected individuals. The tyrosine kinase-containing receptors, trkB and trkC, ...

C S Weickert, D L Ligons, T Romanczyk, G Ungaro, T M Hyde… in Molecular Psychiatry (2005)

Article

A novel protein isoform of catechol O-methyltransferase (COMT): brain expression analysis in schizophrenia and bipolar disorder and effect of Val¹⁵⁸Met genotype

E M Tunbridge, D R Weinberger, P J Harrison in Molecular Psychiatry (2006)

Article

COMT haplotype variation affects human prefrontal function

A Meyer-Lindenberg, T Nichols, J H Callicott, J Ding, B Kolachana… in Molecular Psychiatry (2006)