5 Result(s)

Article

A paternal methyl donor-rich diet altered cognitive and neural functions in offspring mice

Dietary intake of methyl donors, such as folic acid and methionine, shows considerable intra-individual variation in human populations. While it is recognized that maternal departures from the optimum of dieta...

D P Ryan, K S Henzel, B L Pearson, M E Siwek, A Papazoglou, L Guo… in Molecular Psychiatry (2018)

Article

Phase II study of gemcitabine, oxaliplatin in combination with panitumumab in KRAS wild-type unresectable or metastatic biliary tract and gallbladder cancer

Current data suggest that platinum-based combination therapy is the standard first-line treatment for biliary tract cancer. EGFR inhibition has proven beneficial across a number of gastrointestinal malignancie...

A F Hezel, M S Noel, J N Allen, T A Abrams, M Yurgelun… in British Journal of Cancer (2014)

Article

Mechanisms of RNA-induced toxicity in CAG repeat disorders

Several inherited neurodegenerative disorders are caused by CAG trinucleotide repeat expansions, which can be located either in the coding region or in the untranslated region (UTR) of the respective genes. Po...

R Nalavade, N Griesche, D P Ryan, S Hildebrand, S Krauß in Cell Death & Disease (2013)

Article

Sunitinib in combination with gemcitabine for advanced solid tumours: a phase I dose-finding study

This phase I, dose-finding study determined the maximum tolerated dose (MTD), safety, and pharmacokinetics of sunitinib plus gemcitabine in patients with advanced solid tumours.

M D Michaelson, A X Zhu, D P Ryan, D F McDermott, G I Shapiro… in British Journal of Cancer (2013)

Article

Oxaliplatin-induced Evan’s syndrome

C C Earle, W Y Chen, D P Ryan, R J Mayer in British Journal of Cancer (2001)