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  1. Article

    Open Access

    Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial

    M Larrayoz, M J J Rose-Zerilli, L Kadalayil, H Parker, S Blakemore, J Forster… in Leukemia (2017)

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  2. Article

    Open Access

    Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukaemia

    Histone methyltransferases (HMTs) are important epigenetic regulators of gene transcription and are disrupted at the genomic level in a spectrum of human tumours including haematological malignancies. Using hi...

    H Parker, M J J Rose-Zerilli, M Larrayoz, R Clifford, J Edelmann, S Blakemore… in Leukemia (2016)

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  3. Article

    Open Access

    Longitudinal copy number, whole exome and targeted deep sequencing of 'good risk' IGHV-mutated CLL patients with progressive disease

    The biological features of IGHV-M chronic lymphocytic leukemia responsible for disease progression are still poorly understood. We undertook a longitudinal study close to diagnosis, pre-treatment and post relapse...

    M J J Rose-Zerilli, J Gibson, J Wang, W Tapper, Z Davis, H Parker, M Larrayoz… in Leukemia (2016)

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  4. No Access

    Article

    Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial

    J C Strefford, L Kadalayil, J Forster, M J J Rose-Zerilli, A Parker, T T Lin… in Leukemia (2015)

  5. Article

    Open Access

    Quantification of subclonal distributions of recurrent genomic aberrations in paired pre-treatment and relapse samples from patients with B-cell chronic lymphocytic leukemia

    Genome-wide array approaches and sequencing analyses are powerful tools for identifying genetic aberrations in cancers, including leukemias and lymphomas. However, the clinical and biological significance of s...

    S J L Knight, C Yau, R Clifford, A T Timbs, E Sadighi Akha, H M Dréau, A Burns… in Leukemia (2012)

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  6. No Access

    Article

    Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage

    B Britt-Compton, T T Lin, G Ahmed, V Weston, R E Jones, C Fegan, D G Oscier… in Leukemia (2012)

  7. No Access

    Article

    13q deletion anatomy and disease progression in patients with chronic lymphocytic leukemia

    Historically, genes targeted by recurrent chromosomal deletions have been identified within the smallest genomic region shared in all patients, the minimally deleted region (MDR). However, deletions this small...

    H Parker, M J J Rose-Zerilli, A Parker, T Chaplin, R Wade, A Gardiner… in Leukemia (2011)

  8. No Access

    Article

    A subset of Binet stage A CLL patients with TP53 abnormalities and mutated IGHV genes have stable disease

    O G Best, A C Gardiner, Z A Davis, I Tracy, R E Ibbotson, A Majid, M J S Dyer… in Leukemia (2009)

  9. No Access

    Article

    A novel functional assay using etoposide plus nutlin-3a detects and distinguishes between ATM and TP53 mutations in CLL

    O G Best, A C Gardiner, A Majid, R Walewska, B Austen, A Skowronska, R Ibbotson… in Leukemia (2008)

  10. No Access

    Article

    Male preponderance in chronic lymphocytic leukemia utilizing IGHV 1–69

    R Walewska, A Majid, Z Davis, P Dusanjh, D B J Kennedy, D G Oscier, M J S Dyer in Leukemia (2007)

  11. No Access

    Article

    Rapid amplification of immunoglobulin heavy chain switch (IGHS) translocation breakpoints using long-distance inverse PCR

    Molecular cloning of immunoglobulin heavy chain (IGH) translocation breakpoints identifies genes of biological importance in the development of normal and malignant B cells. Long-distance inverse PCR (LDI-PCR) wa...

    T Sonoki, T G Willis, D G Oscier, E L Karran, R Siebert, M J S Dyer in Leukemia (2004)

  12. No Access

    Article

    Novel technique to facilitate the rapid identification of CLL patients utilising the VH3–21 gene

    Z A Davis, R E Ibbotson, C M Wiseman, D G Oscier in Leukemia (2004)

  13. No Access

    Article

    P2X7 polymorphism and chronic lymphocytic leukaemia: lack of correlation with incidence, survival and abnormalities of chromosome 12

    The P2X7 receptor, a plasma membrane ATP-gated ion channel that plays a role in lymphocyte apoptosis, has been suggested as an important contributory factor to the pathogenesis of chronic lymphocytic leukaemia...

    L Y Zhang, R E Ibbotson, J A Orchard, A C Gardiner, R V Seear, A J Chase… in Leukemia (2003)

  14. No Access

    Article

    Proteomic analysis of the cell-surface membrane in chronic lymphocytic leukemia: identification of two novel proteins, BCNP1 and MIG2B

    B-cell-specific plasma-membrane proteins are potential targets for either small molecule or antibody-based therapies. We have sought to annotate proteins expressed at the cell surface membrane in patients with...

    R S Boyd, P J Adam, S Patel, J A Loader, J Berry, N T Redpath, H R Poyser… in Leukemia (2003)

  15. No Access

    Article

    Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations

    The increased or inappropriate expression of genes with oncogenic properties through specific chromosome translocations is an important event in the pathogenesis of B-cell lymphoproliferative diseases. Recent ...

    M M Corcoran, S J Mould, J A Orchard, R E Ibbotson, R M Chapman, A P Boright… in Oncogene (1999)

  16. No Access

    Article

    Ha-ras hypervariable alleles in myelodysplasia

    The somatic mutation of one of the ras oncogenes is now considered to be a critical step in the pathogenesis of many tumours1,2. Circumstantial evidence also suggests that some individuals may be genetically pred...

    S. L. Thein, D. G. Oscier, J. Flint, J. S. Wainscoat in Nature (1986)