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Article
Open AccessGenetic effects influencing risk for major depressive disorder in China and Europe
Major depressive disorder (MDD) is a common, complex psychiatric disorder and a leading cause of disability worldwide. Despite twin studies indicating its modest heritability (~30–40%), extensive heterogeneity...
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Article
Open AccessSNP-based heritability estimates of the personality dimensions and polygenic prediction of both neuroticism and major depression: findings from CONVERGE
Biometrical genetic studies suggest that the personality dimensions, including neuroticism, are moderately heritable (~0.4 to 0.6). Quantitative analyses that aggregate the effects of many common variants have...
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Article
Open AccessMeta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia
Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association sys...
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Article
Bias in genetic association studies and impact factor
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Article
A whole genome association study of neuroticism using DNA pooling
We describe a multistage approach to identify single nucleotide polymorphisms (SNPs) associated with neuroticism, a personality trait that shares genetic determinants with major depression and anxiety disorder...
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Article
Chronic fluoxetine treatment alters behavior, but not adult hippocampal neurogenesis, in BALB/cJ mice
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Article
Erratum: Map** regulatory variants for the serotonin transporter gene based on allelic expression imbalance
Correction to: Molecular Psychiatry (2007) 12: 421–422; doi:10.1038/sj.mp.4001952 Following publication of this article, the authors noted that an incorrect name appeared in the online corresponding author inf...
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Article
Map** regulatory variants for the serotonin transporter gene based on allelic expression imbalance
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Article
Association of the DRD2 gene Taq1A polymorphism and alcoholism: a meta-analysis of case–control studies and evidence of publication bias
We investigated the association of the dopamine D2 receptor (DRD2) Taq1A polymorphism and alcoholism, using meta-analytic techniques, and specifically undertook an investigation of possible publication bias. Pote...
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Article
Rgs 2 gene polymorphisms as modulators of anxiety in humans?
Rgs2 (regulator of G-protein signalling 2) gene recently was reported as a quantitative trait gene for anxious behaviour in mice and male Rgs2 knockout mice have been shown to be more anxious than wildtype mic...
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Article
Erratum: Association of the NRG1 gene and schizophrenia: a meta-analysis
Correction to: Molecular Psychiatry (2006) 11, 539–546. doi:10.1038/sj.mp.4001817 Following the online publication of the above article, the authors noticed the following error: in the footnote to Table 2, ‘rs...
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Article
Association of the NRG1 gene and schizophrenia: a meta-analysis
We investigated the association of the NRG1 gene and schizophrenia using meta-analytic techniques, combining all published data while restricting our analysis to studies investigating the most commonly reported s...
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DCNP1: a novel candidate gene for major depression
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Promise and pitfalls in the meta-analysis of genetic association studies: a response to Sen and Schinka
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Article
Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case–control studies
There is strong evidence for a genetic contribution to schizophrenia, but the contribution of individual candidate genes remains uncertain. We attempted to replicate a recent meta-analysis that reported an ass...
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Article
Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits? A meta-analysis
We attempted to replicate the findings of two recent meta-analyses that personality inventory moderates the association between the serotonin transporter gene and anxiety-related traits. A total of 24 studies ...
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Genetic Polymorphisms and Personality in Healthy Adults: A systematic review and meta-analysis
A meta-analysis was conducted on studies reporting data on associations between candidate genes and human personality. Studies reporting data for psychiatric populations (including organic disease and substanc...
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Article
Spatial memory dissociations in mice lacking GluR1
Gene-targeted mice lacking the AMPA receptor subunit GluR1 (GluR-A) have deficits in hippocampal CA3–CA1 long-term potentiation. We now report that they showed normal spatial reference learning and memory, bot...
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Article
Lack of consistent behavioural effects of Maudsley reactive and non-reactive rats in a number of animal tests of anxiety and activity
Rationale: A number of previous studies have reported that the Maudsley reactive (MR/Har) and non-reactive (MNRA/Har) strains of rats show behavioural and physiological differences consistent with the hypothesis...
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Article
Integration of telomere sequences with the draft human genome sequence
Telomeres are the ends of linear eukaryotic chromosomes. To ensure that no large stretches of uncharacterized DNA remain between the ends of the human working draft sequence and the ends of each chromosome, we...
