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  1. Article

    Results of the randomized phase IIB ADMIRE trial of FCR with or without mitoxantrone in previously untreated CLL

    ADMIRE was a multicenter, randomized-controlled, open, phase IIB superiority trial in previously untreated chronic lymphocytic leukemia. Conventional front-line therapy in fit patients is fludarabine, cyclopho...

    T Munir, D R Howard, L McParland, C Pocock, A C Rawstron, A Hockaday… in Leukemia (2017)

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    Article

    Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial

    J C Strefford, L Kadalayil, J Forster, M J J Rose-Zerilli, A Parker, T T Lin… in Leukemia (2015)

  3. No Access

    Article

    Obinutuzumab as frontline treatment of chronic lymphocytic leukemia: updated results of the CLL11 study

    V Goede, K Fischer, A Engelke, R Schlag, S Lepretre, L F C Montero, M Montillo… in Leukemia (2015)

  4. Article

    Open Access

    Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition

    C Pepper, A G S Buggins, C H Jones, E J Walsby, F Forconi, G Pratt, S Devereux… in Leukemia (2015)

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  5. Article

    Open Access

    Common variation at 12q24.13 (OAS3) influences chronic lymphocytic leukemia risk

    G P Sava, H E Speedy, M C Di Bernardo, M J S Dyer, A Holroyd, N J Sunter… in Leukemia (2015)

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  6. Article

    Open Access

    p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia

    Activation of wild-type p53 with the small molecule sirtuin inhibitor Tenovin-6 (Tnv-6) induces p53-dependent apoptosis in many malignant cells. In contrast, Tnv-6 reduces chronic lymphocytic leukaemia (CLL) c...

    M J Groves, C E Johnson, J James, A R Prescott, J Cunningham… in British Journal of Cancer (2013)

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  7. No Access

    Article

    Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage

    B Britt-Compton, T T Lin, G Ahmed, V Weston, R E Jones, C Fegan, D G Oscier… in Leukemia (2012)

  8. No Access

    Article

    Variant IRF4/MUM1 associates with CD38 status and treatment-free survival in chronic lymphocytic leukaemia

    J M Allan, N J Sunter, J R Bailey, A R Pettitt, R J Harris, C Pepper, C Fegan… in Leukemia (2010)

  9. Article

    Open Access

    Fludarabine-mediated suppression of the excision repair enzyme ERCC1 contributes to the cytotoxic synergy with the DNA minor groove crosslinking agent SJG-136 (NSC 694501) in chronic lymphocytic leukaemia cells

    In this study, we set out to establish whether fludarabine could enhance the DNA interstrand crosslinking capacity of SJG-136 in primary human chronic lymphocytic leukaemia (CLL) cells and thereby offer a rati...

    C Pepper, H Lowe, C Fegan, C Thurieau, D E Thurston… in British Journal of Cancer (2007)

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  10. No Access

    Article

    Highly purified CD38+ and CD38− sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal origin

    CD38 expression is an important prognostic marker in chronic lymphocytic leukemia (CLL) with high levels of CD38 associated with shorter overall survival. In this study, we used gene expression profiling and p...

    C Pepper, R Ward, T T Lin, P Brennan, J Starczynski, M Musson, C Rowntree… in Leukemia (2007)

  11. No Access

    Article

    The role of the bax gene polymorphism G(−248)A in chronic lymphocytic leukemia

    C Fegan, J Starczynski, G Pratt, C Pepper in Leukemia (2006)

  12. No Access

    Article

    CD38+ chronic lymphocytic leukaemia cells co-express high levels of ZAP-70 and are functionally distinct from their CD38− counter-parts

    C Pepper, P Brennan, S Alghazal, R Ward, G Pratt, J Starczynski, T Lin… in Leukemia (2006)

  13. Article

    The platelet glycoprotein Ia/IIa gene polymorphism C807T/G873A: a novel risk factor for retinal vein occlusion

    Retinal vein occlusion (RVO) is associated with hyperhomocysteinaemia and the antiphospholipid syndrome—disorders known to contribute to both arterial and venous thrombosis. In both of these conditions and RVO...

    P M Dodson, J Haynes, J Starczynski, J Farmer, S Shigdar, G Fegan, R J Johnson… in Eye (2003)

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  14. No Access

    Article

    Parenteral glutamine protects hepatic function during bone marrow transplantation

    Hepatic veno-occlusive disease (VOD) of the liver is a common complication following high-dose cytotoxic therapy for bone marrow transplantation (BMT). The major pathological changes are seen in centrilobular ...

    SA Brown, A Goringe, C Fegan, SV Davies, J Giddings… in Bone Marrow Transplantation (1998)