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  1. No Access

    Article

    Targeting TGFβ-activated kinase-1 activation in microglia reduces CAR T immune effector cell-associated neurotoxicity syndrome

    Cancer immunotherapy with chimeric antigen receptor (CAR) T cells can cause immune effector cell-associated neurotoxicity syndrome (ICANS). However, the molecular mechanisms leading to ICANS are not well under...

    Janaki Manoja Vinnakota, Francesca Biavasco, Marius Schwabenland… in Nature Cancer (2024)

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    Article

    Novel NanoLuc substrates enable bright two-population bioluminescence imaging in animals

    Sensitive detection of two biological events in vivo has long been a goal in bioluminescence imaging. Antares, a fusion of the luciferase NanoLuc to the orange fluorescent protein CyOFP, has emerged as a brigh...

    Yichi Su, Joel R. Walker, Yunhee Park, Thomas P. Smith, Lan **ang Liu… in Nature Methods (2020)

  3. Article

    Chimeric Antigen Receptors for Cancer: Progress and Challenges

    Chimeric antigen receptors (CARs) genetically link an antigen-binding domain with cell-signaling domains to redirect immune cell specificity toward antigens expressed on the surface of cancer cells. Progress i...

    Adrienne H. Long, Daniel W. Lee, Crystal L. Mackall in Current Stem Cell Reports (2015)

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