Intraoperative Irradiation
Techniques and Results
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39 Result(s)
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Christopher G. Willett
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Chapter
The Role of Department Chair
The leadership position of a departmental chair can be a positive and rewarding opportunity. These rewards principally stem from the success of the faculty, trainees, staff, and everyone supporting the departm...
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Article
Total Neoadjuvant Therapy (TNT) in Rectal Cancer
This review summarizes the relevant literature on the use of total neoadjuvant therapy (TNT) for patients with locally advanced rectal cancer. It highlights the most notable literature published and briefly di...
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Chapter
Anal Canal Cancer
Radiation therapy with concurrent chemotherapy is the standard treatment for patients with nonmetastatic squamous cell carcinoma of the anal canal. In the studies that established this approach, high rates of ...
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Article
Adjuvant chemotherapy for rectal cancer—an unresolved issue
Several clinical trials have addressed the role of adjuvant chemotherapy following neoadjuvant chemoradiation and surgery for rectal cancer. The recently published EORTC 22921 study adds further debate to the ...
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Article
Open AccessPreoperative chemoradiotherapy for locally advanced gastric cancer
To examine toxicity and outcomes for patients treated with preoperative chemoradiotherapy (CRT) for gastric cancer.
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Article
Potential Novel Drugs to Combine with Radiation in Rectal Cancer
The management of rectal cancer has seen significant advances in surgery, radiation therapy, and chemotherapy in recent years. These advances have translated into improved rates of local and distant disease co...
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Chapter
Esophageal Cancer
Less than 15% of patients diagnosed with esophageal cancer are cured, with half of patients presenting with unresectable or metastatic disease. This chapter will review the natural history and treatment of eso...
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Book
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Recurrent Colorectal Cancer
Aggressive, curative intent treatment approaches in patients with local or regional relapse after resection of primary rectal or colon cancers are often not considered. A growing body of evidence supports an a...
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Chapter
Rationale and Historical Perspective of Intraoperative Irradiation
Most of the major advances in clinical applications of radiation therapy in the treatment of cancer have been due to differences in dose distribution between tumor and dose-limiting normal tissue. For most tum...
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Chapter
Intraoperative Electron Beam Irradiation: Physics and Techniques
Since IORT using electron beams first became popular in the late 1970s and early 1980s, enthusiasm for the technique using conventional accelerators waned. The reasons for this are manyfold. The main factor wa...
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Chapter
Normal-Tissue Tolerance to IOERT, EBRT, or Both: Animal and Clinical Studies
Early clinical investigations of intraoperative electron irradiation (IOERT) as an alternative to conventional external-beam irradiation (EBRT) were based on a limited number of preclinical studies to provide ...
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Chapter
Pancreas Cancer
Despite its infrequency, pancreatic cancer is the fourth leading cause of cancer death in USA with an estimated 42,140 new cases and 36,800 deaths projected in the USA for 2010 [1]. Although mortality rates ha...
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Chapter
Primary Colorectal Cancer
Carcinoma of the rectum is a heterogeneous disease. At one end of the clinical spectrum, a small number of patients present with superficially invasive cancers who are well served by limited procedures, such ...
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Chapter
Retroperitoneal Sarcomas
Retroperitoneal sarcomas are rare, accounting for approximately 10–15% of all soft-tissue sarcomas with an estimated 1,500 cases occurring annually in USA [1, 2]. The most common histologic subtypes include li...
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Chapter
Conclusions and Future Possibilities: IORT
Long-term experience has shown that the use of IORT as a component of treatment in conjunction with other modalities (EBRT, concurrent and maintenance chemotherapy, maximal surgical resection) is feasible and ...
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Chapter
IORT with Electron-Beam, High-Dose-Rate Brachytherapy or Low-KV/Electronic Brachytherapy: Methodological Comparisons
Intraoperative irradiation (IORT) refers to delivery of a single dose of irradiation to a surgically exposed tumor or tumor bed while the normal tissues are protected from the irradiation either by retracting ...
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Book
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Article
Biomarkers of response and resistance to antiangiogenic therapy
No validated biomarkers currently exist for appropriately selecting cancer patients for antiangiogenic therapy. A number of potential systemic, circulating, tissue and imaging biomarkers have emerged as suitab...
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Article
Current management of anal canal cancer
Squamous cell carcinoma of the anal canal historically has been treated with abdominoperineal resection, resulting in high rates of morbidity and local recurrence. Pioneering work led to the finding that radia...
