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Article
Targeted Metabolomics Identifies Pharmacodynamic Biomarkers for BIO 300 Mitigation of Radiation-Induced Lung Injury
Biomarkers serve a number of purposes during drug development including defining the natural history of injury/disease, serving as a secondary endpoint or trigger for intervention, and/or aiding in the selecti...
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Article
Open AccessCorrection: Corrigendum: Pathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse
Scientific Reports 6: Article number: 36579; published online: 15 November 2016; updated: 04 May 2017 This Article contains errors. In the legend of Figure 1, “1.25 cGy min−1” should read: “1.25 Gy min−1”. In ...
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Open AccessToxicity and quality of life report of a phase II study of stereotactic body radiotherapy (SBRT) for low and intermediate risk prostate cancer
Clinical data indicates that delivery of larger daily doses of radiation may improve the therapeutic ratio for prostate cancer compared to conventional fractionation. A phase II study of stereotactic body radi...
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Article
Open AccessPathophysiological mechanisms underlying phenotypic differences in pulmonary radioresponse
Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and ...
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Chapter
Redox-Based Therapeutics for Prevention, Mitigation, and Treatment of Lung Injury Secondary to Radiation Exposure
The lungs are among the most radio-intolerant organs. Prevention, mitigation, and/or treatment of lung damage are crucial to reducing morbidity/mortality following radiation exposure in which the majority or a...
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Chapter
Molecular Mechanisms of Radiation Induced Injury
Radiation-induced normal tissue injury represents a major impediment to the successful achievement of the desired clinical outcome from radiation therapy (RT) for cancer patients; usually improved local contro...
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Lung
The lungs are particularly sensitive to RT, and are often the primary dose-limiting structure during thoracic therapy.
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Biodetection and Biointervention: Cytokine Pathways as a Rationale for Anti-cytokine Interventions Post-Radiation
Recent advances in our understanding of the molecular events underlying the pathogenesis of radiation-induced normal tissue injury has opened up the possibility of biologically based interventions to prevent, ...
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Article
Erratum to: Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities
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Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities
The most efficacious Mn(III) porphyrinic (MnPs) scavengers of reactive species have positive charges close to the Mn site, whereby they afford thermodynamic and electrostatic facilitation for the reaction with...
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Article
Prognostic Significance of Carbonic Anhydrase IX (CA-IX), Endoglin (CD105) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in Breast Cancer Patients
The aim of this study was to examine the prognostic significance of carbonic anhydrase IX (CA-IX), an endogenous marker for tumor hypoxia; endoglin (CD105), a proliferation-associated and hypoxia-inducible gly...
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Chapter
Normal-Tissue Tolerance to IOERT, EBRT, or Both: Animal and Clinical Studies
Early clinical investigations of intraoperative electron irradiation (IOERT) as an alternative to conventional external-beam irradiation (EBRT) were based on a limited number of preclinical studies to provide ...
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Radiation-Induced Lung and Heart Toxicity
For many patients with lung cancer, thoracic radiation therapy (TRT) is an integral part of their treatment. The effect of TRT on normal structures is an important consideration when optimizing treatment plans...
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Article
Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer
Purpose The prognostic significance of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) expression remains unestablished, although EGFR and COX-2 are frequently overexpressed in non-small cell...
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Article
Complete pathological response to bevacizumab and chemoradiation in advanced rectal cancer
Localized rectal adenocarcinoma responds well to 5-fluorouracil/radiation-based therapy. Willett et al. present the case of a 55-year-old woman who was diagnosed with extensive and locally invasive carcinoma of t...
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Open AccessOverexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity
Acute RT-induced damage to the lung is characterized by inflammatory changes, which proceed to the development of fibrotic lesions in the late phase of injury. Ultimately, complete structural ablation will ens...
