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Article
Incidence of Brain Metastasis as First Event in Patients with Esophageal Carcinoma: a Report from Three Prospective Alliance Clinical Trials
Historically, reported incidence of brain metastasis secondary to esophageal carcinoma is low. We sought to determine the incidence of brain metastasis in a contemporary cohort of patients with carcinoma of th...
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Article
Protecting privacy and promoting learning: blockchain and privacy preserving technology should inform new ethical guidelines for health data
Our current legal protections and ethical oversight have been insufficient for guarding against ethical violations involving our health data in the modern age. Concerns regarding the governance and privacy of ...
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Article
Open AccessAdjuvant chemoradiation in pancreatic cancer: impact of radiotherapy dose on survival
To evaluate the impact of radiation dose on overall survival (OS) in patients treated with adjuvant chemoradiation (CRT) for pancreatic ductal adenocarcinoma (PDAC).
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Article
Open AccessPrimary histiocytic sarcoma of the central nervous system: a case report with platelet derived growth factor receptor mutation and PD-L1/PD-L2 expression and literature review
Histiocytic sarcoma (HS) is an aggressive malignant neoplasm. HS in the central nervous system is exceptionally rare and associated with a poor prognosis. This report documents a case of primary HS of the cent...
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Article
Repeated measures analyses of dermatitis symptom evolution in breast cancer patients receiving radiotherapy in a phase 3 randomized trial of mometasone furoate vs placebo (N06C4 [alliance])
Radiotherapy-related dermatological toxicities over time have not been well quantified. We examined during and immediately following radiation therapy skin toxicities over time in a randomized study of mometas...
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Article
Open AccessOutcomes of Stereotactic Body Radiotherapy (SBRT) treatment of multiple synchronous and recurrent lung nodules
Stereotactic body radiotherapy (SBRT) is evolving into a standard of care for unresectable lung nodules. Local control has been shown to be in excess of 90% at 3 years. However, some patients present with sync...
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Article
Assessment of patient-reported measures of bowel function before and after pelvic radiotherapy: an ancillary study of the North Central Cancer Treatment Group study N00CA
The Bowel Function Questionnaire (BFQ) has been used in clinical trials to assess symptoms during and after pelvic radiotherapy (RT). This study evaluated the importance of symptoms in the BFQ from a patient p...
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Article
Primary pineal tumors: outcome and prognostic factors—a study from the Rare Cancer Network (RCN)
To better define outcome and prognostic factors in primary pineal tumors.
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Article
Open AccessThe clinical case for proton beam therapy
Over the past 20 years, several proton beam treatment programs have been implemented throughout the United States. Increasingly, the number of new programs under development is growing. Proton beam therapy has...
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Article
Using the Skindex-16 and Common Terminology Criteria for Adverse Events to assess rash symptoms: results of a pooled-analysis (N0993)
Historically, skin toxicity has been assessed in prospective clinical trials using the clinician-reported National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE). The patient-reported ...
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Article
Open AccessClinical outcomes and toxicity using Stereotactic Body Radiotherapy (SBRT) for advanced cholangiocarcinoma
To report single-institutional clinical outcomes and toxicity with SBRT for cholangiocarcinoma.
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Article
Open AccessAcute and late toxicities of radiotherapy for patients with discoid lupus erythematosus: a retrospective case-control study
The purpose of this study was to evaluate acute and late toxicities of radiotherapy for patients with discoid lupus erythematosus (DLE).
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Article
Code completion of multiple keywords from abbreviated input
Abbreviation Completion is a novel technique to improve the efficiency of code-writing by supporting code completion of multiple keywords based on non-predefined abbreviated input—a different approach from con...
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Article
Open AccessIntensity-modulated radiotherapy for squamous cell carcinoma of the anal canal: Efficacy of a low daily dose to clinically negative regions
We aimed to assess outcomes of patients with anal cancer who underwent intensity-modulated radiotherapy (IMRT) and received less than 1.80 Gy/day.
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Article
Open AccessEvaluation of adjuvant chemoradiation therapy for ampullary adenocarcinoma: the Johns Hopkins Hospital - Mayo Clinic collaborative study
The role of adjuvant chemoradiation therapy for ampullary carcinoma is unknown. Previous literature suggests that certain populations with high risk factors for recurrence may benefit from adjuvant chemoradiat...
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Pancreas Cancer
Despite its infrequency, pancreatic cancer is the fourth leading cause of cancer death in USA with an estimated 42,140 new cases and 36,800 deaths projected in the USA for 2010 [1]. Although mortality rates ha...
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Gastric Cancer
Gastric cancer has experienced a marked change in prevalence during the last few decades. While in some countries, as in the Far East, gastric cancer continues to be a national health problem, the incidence in...
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Article
Marital Status and Quality of Life in Patients with Esophageal Cancer or Barrett's Esophagus: The Mayo Clinic Esophageal Adenocarcinoma and Barrett’s Esophagus Registry Study
Patients with esophageal carcinoma (EC) report deficits in quality of life (QOL), depending on the extent of malignant disease and the goals of treatment at the time of QOL measurement.
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Article
Cumulative Morbidity and Late Mortality in Long-Term Survivors of Exocrine Pancreas Cancer
Less than 5% of patients diagnosed with exocrine pancreas cancer live to be long-term survivors (5+ years after diagnosis). As a result, few studies have focused on these patients’ cumulative, cancer-related m...
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Article
Radiation-induced optic neuritis after pituitary adenoma radiosurgery in a patient with multiple sclerosis: case report
Objective and Importance To describe a rare case of optic neuritis onset after Gamma Knife stereotactic radiosurgery. Clinical Presentation Nine years after transsphenoidal subtotal resec...
