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Article
Open AccessAll-suture anchor size and drill angle influence load to failure in a porcine model of subpectoral biceps tenodesis, a biomechanical study
Tenodesis of the long head of the biceps tendon is frequently performed in shoulder surgery, and all-suture anchors have become more popular as fixation methods. However, uncertainty still exists regarding the...
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Article
Open AccessIntegrated monitoring and modeling to disentangle the complex spatio-temporal dynamics of urbanized streams under drought stress
We have a poor understanding of how urban drainage and other engineered components interact with more natural hydrological processes in green and blue spaces to generate stream flow. This limits the scientific...
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Article
Open AccessPartial ruptures of the distal triceps tendons show only slightly lower ultimate load to failure: a biomechanical study
Partial ruptures of the distal triceps tendon are usually treated surgically from a size of > 50% tendon involvement. The aim of this study was to compare the ultimate load to failure of intact triceps tendons...
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Article
Open AccessQuantifying heterogeneity in ecohydrological partitioning in urban green spaces through the integration of empirical and modelling approaches
Urban green spaces (UGS) can help mitigate hydrological impacts of urbanisation and climate change through precipitation infiltration, evapotranspiration and groundwater recharge. However, there is a need to u...
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Protocol
Assessment of HDAC Inhibitor-Induced Endoplasmic Reticulum (ER) Stress
The endoplasmic reticulum (ER) is a multifunctional cell organelle which is important for the folding and processing of proteins. Different endogenous and exogenous factors can disturb the ER homeostasis, caus...
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Protocol
Assessment of Mitochondrial Dysfunctions After Sirtuin Inhibition
Posttranslational modifications are important for protein functions and cellular signaling pathways. The acetylation of lysine residues is catalyzed by histone acetyltransferases (HATs) and removed by histone ...
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Article
Open AccessA comparative study of integral and coupled approaches for modeling hydraulic exchange processes across a rippled streambed
Although both are crucial parts of the hydrological cycle, groundwater and surface water had traditionally been addressed separately. In recent decades, considering them as a single hydrological continuum in l...
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Article
Open AccessIn vitro-Amplifikation humaner hämatopoetischer Stammzellen im 3D-System
A promising strategy to increase the numbers of hematopoietic stem cells (HSCs) for clinical applications, like stem cell transplantation, is offered by advanced in vitro culture systems. We developed artificial ...
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Article
Open AccessGlobal metabolic alterations in colorectal cancer cells during irinotecan-induced DNA replication stress
Metabolic adaptations can allow cancer cells to survive DNA-damaging chemotherapy. This unmet clinical challenge is a potential vulnerability of cancer. Accordingly, there is an intense search for mechanisms t...
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Article
Open AccessTight association of autophagy and cell cycle in leukemia cells
Autophagy plays an essential role in maintaining cellular homeostasis and in the response to cellular stress. Autophagy is also involved in cell cycle progression, yet the relationship between these processes ...
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Article
Open AccessTeachers and trainers in adult education–Investigating the dimensionality of their knowledge about methods and concepts of teaching and learning
Knowledge about methods and concepts of teaching and learning is considered an important aspect of the pedagogical-psychological knowledge (PPK) of teachers in adult and continuing education (ACE) for designin...
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Article
Open AccessMap** protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products has been shown to accumulate during aging...
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Article
Open AccessMolecular characterization of hematopoietic stem cells after in vitro amplification on biomimetic 3D PDMS cell culture scaffolds
Hematopoietic stem cell (HSC) transplantation is successfully applied since the late 1950s. However, its efficacy can be impaired by insufficient numbers of donor HSCs. A promising strategy to overcome this hu...
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Article
Open AccessATR regulates neuronal activity by modulating presynaptic firing
Ataxia Telangiectasia and Rad3-related (ATR) protein, as a key DNA damage response (DDR) regulator, plays an essential function in response to replication stress and controls cell viability. Hypomorphic mutati...
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Article
Open AccessCooperative treatment effectiveness of ATR and HSP90 inhibition in Ewing’s sarcoma cells
Ewing's sarcoma is an aggressive childhood malignancy whose outcome has not substantially improved over the last two decades. In this study, combination treatments of the HSP90 inhibitor AUY922 with either the...
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Article
On the making of Ptolemy’s star catalog
The assumption that Ptolemy adopted star coordinates from a star catalog by Hipparchus is investigated based on Hipparchus’ equatorial star coordinates in his Commentary on the phenomena of Aratus and Eudoxus. Si...
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Article
Open AccessThe protective role of intracellular glutathione in Saccharomyces cerevisiae during lignocellulosic ethanol production
To enhance the competitiveness of industrial lignocellulose ethanol production, robust enzymes and cell factories are vital. Lignocellulose derived streams contain a cocktail of inhibitors that drain the cell ...
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Chapter
Prägung akademischer Gründer durch persönliche Beziehungen am Beispiel von FunSurf
Mit der Smartwatch von FunSurf sollen Kitesurfer zukünftig ihre Performance in Echtzeit erfassen und sich im Rahmen von globalen und lokalen Bestenlisten mit anderen vergleichen können. Träger dieser Geschäfts...
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Article
The sirtuin 1/2 inhibitor tenovin-1 induces a nonlinear apoptosis-inducing factor-dependent cell death in a p53 null Ewing’s sarcoma cell line
The sirtuin 1/2 inhibitor tenovin-1 activates p53 and may have potential in the management of cancer. Here, we investigated the responsiveness of Ewing’s sarcoma cells to tenovin-1. We examined its effects in ...
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Article
Open AccessLehrkräfte in der Erwachsenen- und Weiterbildung – Zusammenhänge zwischen Vorbildung und Erfahrung mit dem Wissen über Lehr-Lernmethoden und -konzepte
Das Wissen über Lehr-Lernmethoden und -konzepte gilt als ein wichtiger Aspekt des pädagogisch-psychologischen Wissens von Lehrkräften in der Erwachsenen- und Weiterbildung (EB/WB) für die Gestaltung von Lehr-L...
